Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/18243
Title
Association between the Mediterranean Diet and Metabolic Syndrome with Serum Levels of miRNA in Morbid Obesity.
Author(s)
Date issued
2021-01-29
Language
Inglés
Document type
research article
Abstract
The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.
Subject
MESH
Cardiometabolic Risk Factors | Diabetes Mellitus, Type 2 | Diet Surveys | Diet, Mediterranean | Eating | Female | Humans | Incidence | Male | Metabolic Syndrome | MicroRNAs | Middle Aged | Obesity, Morbid | Patient Compliance
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