Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/17447
Title
Prediction of hepatic fibrosis in patients coinfected with HIV and hepatitis C virus based on genetic markers
Author(s)
Fernandez-Rodriguez, Amanda ISCIII | Berenguer, Juan | Jimenez-Sousa, Maria Angeles ISCIII | Guzman-Fulgencio, Maria ISCIII | Micheloud, Dariela | Miralles, Pilar | López, Juan Carlos | Bellón, José María | Aldamiz-Echevarria, Teresa | Garcia-Broncano, Pilar ISCIII | Carrero, Ana | Alvarez, Emilio | Resino, Salvador ISCIII
Date issued
2013-12-15
Citation
J Acquir Immune Defic Syndr. 2013 Dec 15;64(5):434-42.
Language
Inglés
Document type
research article
Abstract
Objective: To assess the ability of the cirrhosis risk score (CRS) to predict liver fibrosis progression in HIV/hepatitis C virus (HCV)-coinfected patients. Design: Retrospective follow-up study. Methods: Based on a minimum follow-up time of 10 years with HCV infection, 190 HIV/HCV-coinfected patients were classified according to their METAVIR score: (1) 25 nonprogressor patients who did not develop fibrosis (F0) and (2) 165 progressor patients who developed fibrosis (F ≥ 1). Seven polymorphisms of CRS signature and IL28B genotype were performed using the GoldenGate assay. The CRS signature was calculated by naive Bayes formula as previously described. Results: Nonprogressors had CRS values significantly lower than progressors (0.61 versus 0.67; P = 0.043). Among the progressors, we observed similar CRS values through all the fibrosis stages (F1/F2/F3/F4). The percentage of patients with CRS > 0.70 (high risk of developing fibrosis) was higher in progressors than in nonprogressors; but the percentages with values between 0.50 and 0.70 (intermediate risk) and <0.50 (low risk) were quite similar for each of the fibrosis stages (P = 0.047). The area under the receiver-operating characteristic curve of CRS for discriminating nonprogressor versus progressor was 0.625 (P = 0.043). When clinical variables were considered (age at HCV infection, intravenous drug use, gender, IL28B, and HCV genotype), the area under the receiver-operating characteristic curve of CRS improved up to 0.739 (P < 0.001). Conclusions: CRS itself seems not to be a good marker for identifying HIV/HCV-coinfected patients who are at high risk of developing liver fibrosis. However, CRS score coupled with clinical factors might help to distinguish between nonprogressors and progressors patients.
Subject
MESH
Genetic Markers | Adolescent | Adult | Coinfection | Female | Follow-Up Studies | HIV Infections | Hepatitis C, Chronic | Humans | Liver Cirrhosis | Male | Middle Aged | Polymorphism, Single Nucleotide | Prognosis | Retrospective Studies | Young Adult
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DOI
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