Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/17236
Título
IL28RA polymorphism (rs10903035) is associated with insulin resistance in HIV/HCV-coinfected patients
Autor(es)
Jimenez-Sousa, Maria Angeles ISCIII | Berenguer, J | Fernandez-Rodriguez, Amanda ISCIII | Micheloud, D | Guzman-Fulgencio, Maria ISCIII | Miralles, P | Pineda-Tenor, Daniel ISCIII | Garcia-Alvarez, Monica ISCIII | López, J C | Aldámiz-Echevarria, T | Carrero, A | Resino, Salvador ISCIII
Fecha de publicación
2014-03
Cita
J Viral Hepat. 2014 Mar;21(3):189-97.
Idioma
Inglés
Tipo de documento
research article
Resumen
Hepatitis C virus (HCV) infection is associated with insulin resistance (IR), although mechanisms leading to IR in these patients are not completely understood. The aim of this study was to evaluate the association of interleukin 28B (IL28B) and interleukin 28 receptor alpha (IL28RA) polymorphisms with IR among human immunodeficiency virus (HIV)/HCV-coinfected patients. We carried out a cross-sectional study on 203 patients. IL28B (rs8099917) and IL28RA (rs10903035) polymorphisms were genotyped by GoldenGate(®) assay. IR was defined as homeostatic model assessment (HOMA) values ≥3.00. Univariate and multivariate generalized linear models (GLM) were used to compare HOMA values and the percentage of patients with IR according to IL28B and IL28RA genotypes. In total, 32% (n = 65/203) of the patients had IR. IL28B rs8099917 TT was not significantly associated with HOMA values and IR. In contrast, rs10903035 AA was significantly associated with high HOMA values taking into account all patients (P = 0.024), as well as the subgroups of patients with significant fibrosis (P = 0.047) and infected with HCV genotype 3 (P = 0.024). Additionally, rs10903035 AA was significantly associated with IR (HOMA ≥3.00) in all patients (adjusted odds ratio (aOR) = 2.02; P = 0.034), in patients with significant fibrosis (aOR = 2.86; P = 0.039) and HCV genotype 3 patients (aOR = 4.89; P = 0.031). In conclusions, IL28RA polymorphism (rs10903035) seems to be implicated in the glucose homeostasis because AA genotype increases the likelihood of IR, but this association was different depending on hepatic fibrosis and HCV genotype.
Palabras clave
MESH
Coinfection | Polymorphism, Genetic | Adult | CD4 Lymphocyte Count | Cross-Sectional Studies | Female | Genetic Association Studies | Genotype | HIV Infections | HIV-1 | Hepacivirus | Hepatitis C, Chronic | Humans | Insulin Resistance | Interferons | Interleukins | Male | Odds Ratio | Receptors, Cytokine | Viral Load
Versión en línea
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