dc.contributor.author | Ovadia, Samuel | |
dc.contributor.author | Özcan, Alaz | |
dc.contributor.author | Hidalgo, Andres | |
dc.date.accessioned | 2023-07-17T09:24:47Z | |
dc.date.available | 2023-07-17T09:24:47Z | |
dc.date.issued | 2023-06-01 | |
dc.identifier.citation | J Leukoc Biol. 2023 Jun 1;113(6):555-566 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16259 | |
dc.description.abstract | The circadian clock has sway on a myriad of physiological targets, among which the immune and inflammatory systems are particularly prominent. In this review, we discuss how neutrophils, the wildcard of the immune system, are regulated by circadian oscillations. We describe cell-intrinsic and extrinsic diurnal mechanisms governing the general physiology and function of these cells, from purely immune to homeostatic. Repurposing the concepts discovered in other cell types, we then speculate on various uncharted avenues of neutrophil-circadian relationships, such as topology, metabolism, and the regulation of tissue clocks, with the hope of identifying exciting new avenues of work in the context of circadian immunity. | es_ES |
dc.description.sponsorship | This study has been possible through grants R01AI165661 from
the National Institutes of Health, RTI2018-095497-B-I00 from
Ministerio de Ciencia e Innovacion, HR17_00527 from Fundación
La Caixa, and FET-OPEN (no. 861878) from the European
Commission. A.O is supported by the Swiss National Science
Foundation (P500PB-206852). The CNIC is supported by
Ministerio de Ciencia e Innovacion and the Pro CNIC Foundation
and is a Severo Ochoa Center of Excellence (CEX2020-001041-S).
Conflict of interest statement. A.H. is a paid consultant for Calida
Therapeutics. The other authors declare no conflict of interest. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Oxford University Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Neutrophils | es_ES |
dc.subject.mesh | Circadian Clocks | es_ES |
dc.subject.mesh | Circadian Rhythm | es_ES |
dc.subject.mesh | Homeostasis | es_ES |
dc.title | The circadian neutrophil, inside-out. | es_ES |
dc.type | review | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 36999376 | es_ES |
dc.format.volume | 113 | es_ES |
dc.format.number | 6 | es_ES |
dc.format.page | 555 | es_ES |
dc.identifier.doi | 10.1093/jleuko/qiad038 | es_ES |
dc.contributor.funder | National Institutes of Health (Estados Unidos) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea | es_ES |
dc.contributor.funder | Swiss National Science Foundation | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1938-3673 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1093/jleuko/qiad038 | es_ES |
dc.identifier.journal | Journal of leukocyte biology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/FET-OPEN/861878 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-095497-B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR17_00527 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |