Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/16259
Title
The circadian neutrophil, inside-out.
Author(s)
Date issued
2023-06-01
Citation
J Leukoc Biol. 2023 Jun 1;113(6):555-566
Language
Inglés
Document type
review
Abstract
The circadian clock has sway on a myriad of physiological targets, among which the immune and inflammatory systems are particularly prominent. In this review, we discuss how neutrophils, the wildcard of the immune system, are regulated by circadian oscillations. We describe cell-intrinsic and extrinsic diurnal mechanisms governing the general physiology and function of these cells, from purely immune to homeostatic. Repurposing the concepts discovered in other cell types, we then speculate on various uncharted avenues of neutrophil-circadian relationships, such as topology, metabolism, and the regulation of tissue clocks, with the hope of identifying exciting new avenues of work in the context of circadian immunity.
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