dc.contributor.author | Richterová, D | |
dc.contributor.author | Govarts, E | |
dc.contributor.author | Fábelová, L | |
dc.contributor.author | Rausová, K | |
dc.contributor.author | Rodriguez Martin, L | |
dc.contributor.author | Gilles, L | |
dc.contributor.author | Remy, S | |
dc.contributor.author | Colles, A | |
dc.contributor.author | Rambaud, L | |
dc.contributor.author | Riou, M | |
dc.contributor.author | Gabriel, C | |
dc.contributor.author | Sarigiannis, D | |
dc.contributor.author | Pedraza-Diaz, Susana | |
dc.contributor.author | Ramos, Juan Jose | |
dc.contributor.author | Kosjek, T | |
dc.contributor.author | Snoj Tratnik, J | |
dc.contributor.author | Lignell, S | |
dc.contributor.author | Gyllenhammar, I | |
dc.contributor.author | Thomsen, C | |
dc.contributor.author | Haug, L S | |
dc.contributor.author | Kolossa-Gehring, M | |
dc.contributor.author | Vogel, N | |
dc.contributor.author | Franken, C | |
dc.contributor.author | Vanlarebeke, N | |
dc.contributor.author | Bruckers, L | |
dc.contributor.author | Stewart, L | |
dc.contributor.author | Sepai, O | |
dc.contributor.author | Schoeters, G | |
dc.contributor.author | Uhl, M | |
dc.contributor.author | Castaño, Argelia | |
dc.contributor.author | Esteban-Lopez, Marta | |
dc.contributor.author | Göen, T | |
dc.contributor.author | Palkovicova Murinova, Lubica | |
dc.date.accessioned | 2023-05-23T07:23:38Z | |
dc.date.available | 2023-05-23T07:23:38Z | |
dc.date.issued | 2023-01 | |
dc.identifier.citation | Int J Hyg Environ Health. 2023 Jan;247:114057. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16109 | |
dc.description.abstract | Background: Perfluoroalkyl substances (PFAS) are man-made fluorinated chemicals, widely used in various types of consumer products, resulting in their omnipresence in human populations. The aim of this study was to describe current PFAS levels in European teenagers and to investigate the determinants of serum/plasma concentrations in this specific age group. Methods: PFAS concentrations were determined in serum or plasma samples from 1957 teenagers (12-18 years) from 9 European countries as part of the HBM4EU aligned studies (2014-2021). Questionnaire data were post-harmonized by each study and quality checked centrally. Only PFAS with an overall quantification frequency of at least 60% (PFOS, PFOA, PFHxS and PFNA) were included in the analyses. Sociodemographic and lifestyle factors were analysed together with food consumption frequencies to identify determinants of PFAS exposure. The variables study, sex and the highest educational level of household were included as fixed factors in the multivariable linear regression models for all PFAS and each dietary variable was added to the fixed model one by one and for each PFAS separately. Results: The European exposure values for PFAS were reported as geometric means with 95% confidence intervals (CI): PFOS [2.13 μg/L (1.63-2.78)], PFOA ([0.97 μg/L (0.75-1.26)]), PFNA [0.30 μg/L (0.19-0.45)] and PFHxS [0.41 μg/L (0.33-0.52)]. The estimated geometric mean exposure levels were significantly higher in the North and West versus the South and East of Europe. Boys had significantly higher concentrations of the four PFAS compared to girls and significantly higher PFASs concentrations were found in teenagers from households with a higher education level. Consumption of seafood and fish at least 2 times per week was significantly associated with 21% (95% CI: 12-31%) increase in PFOS concentrations and 20% (95% CI: 10-31%) increase in PFNA concentrations as compared to less frequent consumption of seafood and fish. The same trend was observed for PFOA and PFHxS but not statistically significant. Consumption of eggs at least 2 times per week was associated with 11% (95% CI: 2-22%) and 14% (95% CI: 2-27%) increase in PFOS and PFNA concentrations, respectively, as compared to less frequent consumption of eggs. Significantly higher PFOS concentrations were observed for participants consuming offal (14% (95% CI: 3-26%)), the same trend was observed for the other PFAS but not statistically significant. Local food consumption at least 2 times per week was associated with 40% (95% CI: 19-64%) increase in PFOS levels as compared to those consuming local food less frequently. Conclusion: This work provides information about current levels of PFAS in European teenagers and potential dietary sources of exposure to PFAS in European teenagers. These results can be of use for targeted monitoring of PFAS in food. | es_ES |
dc.description.sponsorship | This work was supported by the European Union’s Horizon 2020 research and innovation programme under Grant agreement No 733032 HBM4EU (www.HBM4EU.eu), and received co-funding from the authors’ organizations: Riksmaten Adolescents: Riksmaten Adolescents was performed by the Swedish Food Agency with financial support from the Swedish Environmental Protection Agency and the Swedish Civil Contingencies Agency. NEB II: The Norwegian Institute of Public Health (NIPH) has contributed to funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements have partly been funded by the Research Council of Norway through research projects (275903 and 268465) PCB cohort follow-up: PCB cohort follow-up received additional funding from the Ministry of Health of the Slovak Republic, program 07B0103. BEA: BEA study was funded by the Spanish Ministry of Agriculture, Fisheries and Food and the Instituto de Salud Carlos III (SEG 1321/15) SLO-CRP: The Slovenian SLO-CRP study was co-financed by the Jozef Stefan Institute program P1- 0143, and a national project “Exposure of children and adolescents to selected chemicals through their habitat environment” (grant agreement No. C2715-16-634802). CROME: CROME study was co-funded by the European Commission research funds of Horizon 2020. ESTEBAN: ESTEBAN study was funded by Santé Publique France and the French ministries of Health and the Environment. GerES V-sub: The funding of the German Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection is gratefully acknowledged. FLEHS IV: The Flemish Center of Expertise on Environment and Health is funded by the Government of Flanders, Department of Environment & Spatial Development. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Adolescents | es_ES |
dc.subject | Determinants | es_ES |
dc.subject | Exposure | es_ES |
dc.subject | Food consumption | es_ES |
dc.subject | HBM4EU | es_ES |
dc.subject | Perfluoroalkyl substances | es_ES |
dc.subject.mesh | Fluorocarbons | es_ES |
dc.subject.mesh | Alkanesulfonic Acids | es_ES |
dc.subject.mesh | Environmental Pollutants | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Adolescent | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Fishes | es_ES |
dc.subject.mesh | Diet | es_ES |
dc.subject.mesh | Linear Models | es_ES |
dc.subject.mesh | Data Collection | es_ES |
dc.title | PFAS levels and determinants of variability in exposure in European teenagers - Results from the HBM4EU aligned studies (2014-2021) | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 36327670 | es_ES |
dc.format.volume | 247 | es_ES |
dc.format.page | 114057 | es_ES |
dc.identifier.doi | 10.1016/j.ijheh.2022.114057 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. H2020 | es_ES |
dc.contributor.funder | Swedish Environmental Protection Agency | es_ES |
dc.contributor.funder | Swedish Civil Contingencies Agency | es_ES |
dc.contributor.funder | The Research Council of Norway | es_ES |
dc.contributor.funder | Ministry of Health (República Checa) | es_ES |
dc.contributor.funder | Ministerio de Agricultura, Pesca y Alimentación (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Jožef Stefan Institute | es_ES |
dc.contributor.funder | Ministère de la Santé (Francia) | es_ES |
dc.contributor.funder | Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (Alemania) | es_ES |
dc.contributor.funder | Government of Flanders | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1618-131X | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.ijheh.2022.114057 | es_ES |
dc.identifier.journal | International journal of hygiene and environmental health | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Sanidad Ambiental | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/733032/EU | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/SEG1321/15 | es_ES |