Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16064
Título
Enhancing SARS-CoV-2 Surveillance through Regular Genomic Sequencing in Spain: The RELECOV Network
Autor(es)
Vazquez-Moron, Sonia ISCIII | Iglesias-Caballero, Maria ISCIII | Lepe, José Antonio | Garcia, Federico | Melón, Santiago | Marimón, Jose M | García de Viedma, Darío | Folgueira, María Dolores | Galán, Juan Carlos | López-Causapé, Carla | Benito-Ruesca, Rafael | Alcoba-Florez, Julia | Gonzalez Candelas, Fernando | de Toro, María | Fajardo, Miguel | Ezpeleta, Carmen | Lázaro, Fernando | Pérez Castro, Sonia | Cuesta de la Plaza, Isabel ISCIII | Zaballos, Ángel ISCIII | Pozo Sanchez, Francisco ISCIII | Casas Flecha, Inmaculada ISCIII | RELECOV Network Members
Fecha de publicación
2023-05
Cita
Int. J. Mol. Sci. 2023, 24(10), 8573.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Millions of SARS-CoV-2 whole genome sequences have been generated to date. However, good quality data and adequate surveillance systems are required to contribute to meaningful surveillance in public health. In this context, the network of Spanish laboratories for coronavirus (RELECOV) was created with the main goal of promoting actions to speed up the detection, analyses, and evaluation of SARS-CoV-2 at a national level, partially structured and financed by an ECDC-HERA-Incubator action (ECDC/GRANT/2021/024). A SARS-CoV-2 sequencing quality control assessment (QCA) was developed to evaluate the network’s technical capacity. QCA full panel results showed a lower hit rate for lineage assignment compared to that obtained for variants. Genomic data comprising 48,578 viral genomes were studied and evaluated to monitor SARS-CoV-2. The developed network actions showed a 36% increase in sharing viral sequences. In addition, analysis of lineage/sublineage-defining mutations to track the virus showed characteristic mutation profiles for the Delta and Omicron variants. Further, phylogenetic analyses strongly correlated with different variant clusters, obtaining a robust reference tree. The RELECOV network has made it possible to improve and enhance the genomic surveillance of SARS-CoV-2 in Spain. It has provided and evaluated genomic tools for viral genome monitoring and characterization that make it possible to increase knowledge efficiently and quickly, promoting the genomic surveillance of SARS-CoV-2 in Spain.
Palabras clave
SARS-CoV-2 | Genomic surveillance Spain | Laboratory network RELECOV | VOCs | Lineages | National QCA | Mutation | Phylogeny
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IIS Aragón - Instituto de Investigación Sanitaria Aragón (Aragón)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > ISCIII > Centro Nacional de Microbiología (CNM)
- Investigación > IIS > i+12 - Instituto de Investigación Hospital 12 de Octubre (Madrid)
- Investigación > IIS > ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
- Investigación > IIS > IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón (Madrid)
- Investigación > IIS > IRYCIS - Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)
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