dc.contributor.author | Antequera, Desireé | |
dc.contributor.author | Carrero, Laura | |
dc.contributor.author | Cunha Alves, Victoria | |
dc.contributor.author | Ferrer, Isidro | |
dc.contributor.author | Hernández-Gallego, Jesús | |
dc.contributor.author | Municio, Cristina | |
dc.contributor.author | Carro, Eva | |
dc.date.accessioned | 2023-04-26T14:06:55Z | |
dc.date.available | 2023-04-26T14:06:55Z | |
dc.date.issued | 2022-07-08 | |
dc.identifier.citation | Biomedicines. 2022 Jul 8;10(7):1645. | es_ES |
dc.identifier.issn | 2227-9059 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15901 | |
dc.description.abstract | Impaired brain clearance mechanisms may result in the accumulation of aberrant proteins that define Alzheimer's disease (AD). The water channel protein astrocytic aquaporin 4 (AQP4) is essential for brain amyloid-β clearance, but it is known to be abnormally expressed in AD brains. The expression of AQPs is differentially regulated during diverse brain injuries, but, whereas AQP4 expression and function have been studied in AD, less is known about AQP5. AQP5 functions include not only water transport but also cell migration mediated by cytoskeleton regulation. Moreover, AQP5 has been reported to be expressed in astrocytes, which are regulated after ischemic and traumatic injury. Additionally, AQP5 is particularly abundant in the salivary glands suggesting that it may be a crucial factor in gland dysfunction associated with AD. Herein, we aim to determine whether AQP5 expression in submandibular glands and the brain was altered in AD. First, we demonstrated impaired AQP5 expression in submandibular glands in APP/PS1 mice and AD patients. Subsequently, we observed that AQP5 expression was upregulated in APP/PS1 cerebral cortex and confirmed its expression both in astrocytes and neurons. Our findings propose AQP5 as a significant role player in AD pathology, in addition to AQP4, representing a potential target for the treatment of AD. | es_ES |
dc.description.sponsorship | This study was supported by grants from Instituto de Salud Carlos III through the project PI2021/00679) and cofounded by the European Union, Hospital Universitario 12 de Octubre Research Institute (2022/0068), FEDER, Comunidad de Madrid (S2017/BMD-3700; NEUROMETAB-CM), and CIBERNED (CB07/502, PI2021/03). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Alzheimer’s disease | es_ES |
dc.subject | Aquaporins | es_ES |
dc.subject | Astrocytes | es_ES |
dc.subject | Neurons | es_ES |
dc.subject | Submandibular gland | es_ES |
dc.title | Differentially Aquaporin 5 Expression in Submandibular Glands and Cerebral Cortex in Alzheimer's Disease | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35884950 | es_ES |
dc.format.volume | 10 | es_ES |
dc.format.number | 7 | es_ES |
dc.format.page | 1645 | es_ES |
dc.identifier.doi | 10.3390/biomedicines10071645 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Research Institute Hospital 12 de Octubre | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Comunidad de Madrid (España) | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/biomedicines10071645 | es_ES |
dc.identifier.journal | Biomedicines | es_ES |
dc.repisalud.centro | ISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC) | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III///PI21 - Proyectos de investigacion en salud (AES 2021). Modalidad proyectos de investigación en salud. (2021)/PI21/00679 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI2021/03 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/CB07/502 | es_ES |