Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15254
Título
Pluripotency Surveillance by Myc-Driven Competitive Elimination of Differentiating Cells.
Autor(es)
Fecha de publicación
2017-09-25
Cita
Dev Cell 2017 Sep 25;42(6):585-599.e4
Idioma
Inglés
Tipo de documento
journal article
Resumen
The mammalian epiblast is formed by pluripotent cells able to differentiate into all tissues of the new individual. In their progression to differentiation, epiblast cells and their in vitro counterparts, embryonic stem cells (ESCs), transit from naive pluripotency through a differentiation-primed pluripotent state. During these events, epiblast cells and ESCs are prone to death, driven by competition between Myc-high cells (winners) and Myc-low cells (losers). Using live tracking of Myc levels, we show that Myc-high ESCs approach the naive pluripotency state, whereas Myc-low ESCs are closer to the differentiation-primed state. In ESC colonies, naive cells eliminate differentiating cells by cell competition, which is determined by a limitation in the time losers are able to survive persistent contact with winners. In the mouse embryo, cell competition promotes pluripotency maintenance by elimination of primed lineages before gastrulation. The mechanism described here is relevant to mammalian embryo development and induced pluripotency.
MESH
Cell Differentiation | Animals | Cell Communication | Cell Lineage | Cell Proliferation | Cell Survival | Cell Tracking | Cells, Cultured | Embryo, Mammalian | Gastrulation | Gene Expression Profiling | Germ Layers | Inheritance Patterns | Mice | Mouse Embryonic Stem Cells | Pluripotent Stem Cells | Proto-Oncogene Proteins c-myc | Time Factors
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