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dc.contributor.authorDíaz-Díaz, Covadonga
dc.contributor.authorFernandez de Manuel, Laura
dc.contributor.authorJimenez-Carretero, Daniel 
dc.contributor.authorMontoya, María Concepción
dc.contributor.authorClavería, Cristina
dc.contributor.authorTorres, Miguel 
dc.date.accessioned2022-12-01T15:42:25Z
dc.date.available2022-12-01T15:42:25Z
dc.date.issued2017-09-25
dc.identifier.citationDev Cell 2017 Sep 25;42(6):585-599.e4es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/15254
dc.description.abstractThe mammalian epiblast is formed by pluripotent cells able to differentiate into all tissues of the new individual. In their progression to differentiation, epiblast cells and their in vitro counterparts, embryonic stem cells (ESCs), transit from naive pluripotency through a differentiation-primed pluripotent state. During these events, epiblast cells and ESCs are prone to death, driven by competition between Myc-high cells (winners) and Myc-low cells (losers). Using live tracking of Myc levels, we show that Myc-high ESCs approach the naive pluripotency state, whereas Myc-low ESCs are closer to the differentiation-primed state. In ESC colonies, naive cells eliminate differentiating cells by cell competition, which is determined by a limitation in the time losers are able to survive persistent contact with winners. In the mouse embryo, cell competition promotes pluripotency maintenance by elimination of primed lineages before gastrulation. The mechanism described here is relevant to mammalian embryo development and induced pluripotency.es_ES
dc.description.sponsorshipWe thank B. Sleckman for the GFP-Myc mice, the CNIC Microscopy unit for the live confocal analysis, the CNIC Genomics and Bioinformatics units for the RNA-seq analysis, J.C. Alonso for video editing, and M. Manzanares, J.A. Enrı´quez, and members of the Torres lab for helpful comments on the manuscript. This work was supported by grants BFU2015-71519-P and RD16/0011/0019 (ISCIII) from the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) and grant P2010/BMD-2315 from the Madrid Regional Government to M.T., and grants (BIO2014-62200-EXP) and (PIFIS-2016) from MEIC to M.C.M. C.D.D. was supported by an FPU grant from the Spanish Ministry of Education, Culture and Sports. The CNIC is supported by the Spanish MEIC and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (MEIC award SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshCell Differentiation es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCell Communication es_ES
dc.subject.meshCell Lineage es_ES
dc.subject.meshCell Proliferation es_ES
dc.subject.meshCell Survival es_ES
dc.subject.meshCell Tracking es_ES
dc.subject.meshCells, Cultured es_ES
dc.subject.meshEmbryo, Mammalianes_ES
dc.subject.meshGastrulation es_ES
dc.subject.meshGene Expression Profiling es_ES
dc.subject.meshGerm Layers es_ES
dc.subject.meshInheritance Patterns es_ES
dc.subject.meshMice es_ES
dc.subject.meshMouse Embryonic Stem Cells es_ES
dc.subject.meshPluripotent Stem Cells es_ES
dc.subject.meshProto-Oncogene Proteins c-myc es_ES
dc.subject.meshTime Factors es_ES
dc.titlePluripotency Surveillance by Myc-Driven Competitive Elimination of Differentiating Cells.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID28919206es_ES
dc.format.volume42es_ES
dc.format.number6es_ES
dc.format.page585es_ES
dc.identifier.doi10.1016/j.devcel.2017.08.011es_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) es_ES
dc.contributor.funderComunidad de Madrid (España) es_ES
dc.contributor.funderMinisterio de Educación, Cultura y Deporte (España) es_ES
dc.contributor.funderFundación ProCNIC es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1878-1551es_ES
dc.relation.publisherversion10.1016/j.devcel.2017.08.011es_ES
dc.identifier.journalDevelopmental celles_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Control Genético del Desarrollo y Regeneración de Órganoses_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/BFU2015-71519-Pes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/RD16/0011/0019es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/P2010/BMD-2315es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/BIO2014-62200-EXPes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PIFIS-2016es_ES


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