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dc.contributor.authorNieto-Ruiz, Ana
dc.contributor.authorGarcía-Santos, José A
dc.contributor.authorVerdejo-Román, Juan
dc.contributor.authorDiéguez, Estefanía
dc.contributor.authorSepúlveda-Valbuena, Natalia
dc.contributor.authorHerrmann, Florian
dc.contributor.authorCerdo, Tomas 
dc.contributor.authorDe-Castellar, Roser
dc.contributor.authorJiménez, Jesús
dc.contributor.authorBermúdez, Mercedes G
dc.contributor.authorPérez-García, Miguel
dc.contributor.authorMiranda, M Teresa
dc.contributor.authorLópez-Sabater, M Carmen
dc.contributor.authorCatena, Andrés
dc.contributor.authorCampoy, Cristina
dc.date.accessioned2022-05-24T08:36:14Z
dc.date.available2022-05-24T08:36:14Z
dc.date.issued2022-03-09
dc.identifier.citationFront Nutr. 2022 Mar 9;9:820224.es_ES
dc.identifier.issn2296-861Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/14476
dc.description.abstractBackground: Adequate nutrient intake during the first few months of life plays a critical role on brain structure and function development. Objectives: To analyze the long-term effects of an experimental infant formula (EF) on neurocognitive function and brain structure in healthy children aged 6 years compared to those fed with a standard infant formula or breastfed. Methods: The current study involved 108 healthy children aged 6 years and participating in the COGNIS Study. At 0-2 months, infants were randomized to receive up to 18 months of life a standard infant formula (SF) or EF enriched with milk fat globule membrane (MFGM), long-chain polyunsaturated fatty acids (LC-PUFAs) and synbiotics. Furthermore, a reference group of breastfed (BF) infants were also recruited. Children were assessed using neurocognitive tests and structural Magnetic Resonance Imaging (MRI) at 6 years old. Results: Experimental infant formula (EF) children showed greater volumes in the left orbital cortex, higher vocabulary scores and IQ, and better performance in an attention task than BF children. EF children also presented greater volumes in parietal regions than SF kids. Additionally, greater cortical thickness in the insular, parietal, and temporal areas were found in children from the EF group than those fed with SF or BF groups. Further correlation analyses suggest that higher volumes and cortical thickness of different parietal and frontal regions are associated with better cognitive development in terms of language (verbal comprehension) and executive function (working memory). Finally, arachidonic acid (ARA), adrenic acid (AdA), docosahexaenoic acid (DHA) levels in cheek cell glycerophospholipids, ARA/DHA ratio, and protein, fatty acid, and mineral intake during the first 18 months of life seem to be associated with changes in the brain structures at 6 years old. Conclusions: Supplemented infant formula with MFGM components, LC-PUFAs, and synbiotics seems to be associated to long-term effects on neurocognitive development and brain structure in children at 6 years old.es_ES
dc.description.sponsorshipThis project has been funded by Laboratorios Ordesa, S.L. Contract University of Granada General Foundation, No. 3349 and SMARTFOODS (CIEN) Contract University of Granada General Foundation, No. 4003, Spanish Ministry of Economy, Industry and Competitiveness. Furthermore, the project has been partially funded by HORIZON 2020 EU DynaHEALTH Project (GA No. 633595).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLC-PUFAses_ES
dc.subjectMFGMes_ES
dc.subjectBreastfeedinges_ES
dc.subjectCognitiones_ES
dc.subjectEarly nutritiones_ES
dc.subjectInfant formulaes_ES
dc.subjectNeuroimaginges_ES
dc.subjectSynbioticses_ES
dc.titleInfant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Studyes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID35356726es_ES
dc.format.volume9es_ES
dc.format.page820224es_ES
dc.identifier.doi10.3389/fnut.2022.820224es_ES
dc.contributor.funderUniversity of Granada (España) es_ES
dc.contributor.funderOrdesa (Spain)es_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) es_ES
dc.contributor.funderUnión Europea. Comisión Europea. H2020 es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fnut.2022.820224es_ES
dc.identifier.journalFrontiers in Nutritiones_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/633595/EUes_ES
dc.rights.accessRightsopen accesses_ES


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