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dc.contributor.authorVaccher, Vincent
dc.contributor.authorEsteban-Lopez, Marta 
dc.contributor.authorCastaño, Argelia 
dc.contributor.authorMol, Hans
dc.contributor.authorHaji-Abbas-Zarrabi, Karin
dc.contributor.authorBury, Daniel
dc.contributor.authorKoch, Holger M
dc.contributor.authorDvorakova, Darina
dc.contributor.authorHajslova, Jana
dc.contributor.authorNübler, Stefanie
dc.contributor.authorKaur Sakhi, Amrit
dc.contributor.authorThomsen, Cathrine
dc.contributor.authorVorkamp, Katrin
dc.contributor.authorGöen, Thomas
dc.contributor.authorAntignac, Jean-Philippe
dc.identifier.citationEnviron Res. 2022 Jul;210:112933.es_ES
dc.description.abstractThe Human Biomonitoring for Europe initiative (HBM4EU) aims to study the exposure of citizens to chemicals and potentially associated health effects. One objective of this project has been to build a network of laboratories able to answer to the requirements of European human biomonitoring studies. Within the HBM4EU quality assurance and quality control scheme (QA/QC), a number of interlaboratory comparison investigations (ICIs) and external quality assurance schemes (EQUASs) were organized to ensure data consistency, comparability and reliability. Bisphenols are among the prioritized substance groups in HBM4EU, including bisphenol A (BPA), bisphenol S (BPS) and bisphenol F (BPF) in human urine. In four rounds of ICI/EQUAS, two target concentration levels were considered, related to around P25 and P95 of the typical exposure distribution observed in the European general population. Special attention was paid to the conjugated phase II metabolites known to be most dominant in samples of environmentally exposed individuals, through the analysis of both native samples and samples fortified with glucuronide forms. For the low level, the average percentage of satisfactory results across the four rounds was 83% for BPA, 71% for BPS and 62% for BPF. For the high level, the percentages of satisfactory results increased to 93% for BPA, 89% for BPS and 86% for BPF. 24 out of 32 participating laboratories (75%) were approved for the analyses of BPA in the HBM4EU project according to the defined criterion of Z-scores for both low and high concentration levels in at least two ICI/EQUAS rounds. For BPS and BPF, the number of qualified laboratories was 18 out of 27 (67%) and 13 out of 28 (46%), respectively. These results demonstrate a strong analytical capability for BPA and BPS in Europe, while improvements may be needed for BPF.es_ES
dc.description.sponsorshipWe gratefully acknowledge funding by the European Union's Horizon 2020 research and innovation programme under the grant agreement No. 733032 HBM4EU. The authors would like to thank the HBM4EU Secretariat at the German Environment Agency for administrative support. The authors acknowledge all the participating and expert laboratories (Table A1, SM) that made the HBM4EU QA/QC programme possible as well as the Management and Advisory Boards of HBM4EU.es_ES
dc.publisherElsevier es_ES
dc.subjectExternal quality assurance scheme (EQUAS)es_ES
dc.subjectHuman biomonitoringes_ES
dc.subjectInterlaboratory comparison investigation (ICI)es_ES
dc.titleEuropean interlaboratory comparison investigations (ICI) and external quality assurance schemes (EQUAS) for the analysis of bisphenol A, S and F in human urine: Results from the HBM4EU projectes_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderUnión Europea. Comisión Europea. H2020 es_ES
dc.contributor.funderGerman Federal Environment Agency es_ES
dc.identifier.journalEnvironmental Researches_ES
dc.repisalud.centroISCIII::Centro Nacional de Sanidad Ambientales_ES
dc.rights.accessRightsopen accesses_ES

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