dc.contributor.author | Toribio, María José | |
dc.contributor.author | Priego-Capote, Feliciano | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Fernandez de Larrea-Baz, Nerea | |
dc.contributor.author | Ruiz Moreno, Emma | |
dc.contributor.author | Castelló Pastor, Adela | |
dc.contributor.author | de Lucas, Maria Pilar | |
dc.contributor.author | Sierra, Maria Angeles | |
dc.contributor.author | Pino, Marina Nieves | |
dc.contributor.author | Martínez-Cortés, Mercedes | |
dc.contributor.author | Luque de Castro, María Dolores | |
dc.contributor.author | Lope Carvajal, Virginia | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.date.accessioned | 2022-05-09T06:38:55Z | |
dc.date.available | 2022-05-09T06:38:55Z | |
dc.date.issued | 2021-10-23 | |
dc.identifier.citation | Nutrients. 2021;13(11):3747. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/14311 | |
dc.description.abstract | The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39-50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE-LC-MS/MS platform. The association between participant's characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes. | es_ES |
dc.description.sponsorship | This study was funded by the Spanish Ministry of Health (EC11–273) and by the Carlos III Institute of Health (PI15CIII/0029). The article presents independent research. The views expressed are those of the authors and not necessarily those of the Carlos III Institute of Health. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | 1,25(OH)2D3 | es_ES |
dc.subject | 24,25(OH)2D3 | es_ES |
dc.subject | 25(OH)D3 | es_ES |
dc.subject | Vit D3 | es_ES |
dc.subject | Vitamin D metabolite ratios | es_ES |
dc.title | Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 34836003 | es_ES |
dc.format.volume | 13 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | 3747 | es_ES |
dc.identifier.doi | 10.3390/nu13113747 | es_ES |
dc.contributor.funder | Ministerio de Sanidad (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2072-6643 | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/nu13113747 | es_ES |
dc.identifier.journal | Nutrients | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI15CIII/0029 | es_ES |