Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/14311
Título
Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
Autor(es)
Toribio, María José | Priego-Capote, Feliciano | Perez-Gomez, Beatriz ISCIII | Fernandez de Larrea-Baz, Nerea ISCIII | Ruiz Moreno, Emma ISCIII | Castelló Pastor, Adela | de Lucas, Maria Pilar ISCIII | Sierra, Maria Angeles ISCIII | Pino, Marina Nieves | Martínez-Cortés, Mercedes | Luque de Castro, María Dolores | Lope Carvajal, Virginia ISCIII | Pollan-Santamaria, Marina ISCIII
Fecha de publicación
2021-10-23
Cita
Nutrients. 2021;13(11):3747.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39-50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE-LC-MS/MS platform. The association between participant's characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.
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