Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/13973
Título
Development of an activity disease score in patients with uveitis (UVEDAI)
Autor(es)
Pato, Esperanza | Martin-Martinez, Mª Auxiliadora | Castelló Pastor, Adela ISCIII | Méndez Fernandez, Rosalía | Muñoz-Fernández, Santiago | Cordero-Coma, Miguel | Martinez-Costa, Lucia | Valls, Elia | Reyes, Miguel | Francisco, Félix | Esteban, Mar | Fonollosa, Alex | Sanchez-Alonso, Fernando | Fernández-Espartero, Cruz | Diaz-Valle, Teresa | Carrasco, José Miguel | Beltran-Catalán, Emma | Hernández-Garfella, Marisa | Hernández, María Victoria | Pelegrin, Laura | Blanco, Ricardo | Díaz Valle, David
Fecha de publicación
2017-04
Cita
Rheumatol Int. 2017;37(4):647-656
Idioma
Inglés
Tipo de documento
journal article
Resumen
To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable. The construct "uveitis inflammatory activity" was defined as any intraocular inflammation that included external structures (cornea) in addition to uvea. Seven domains and 15 items were identified: best-corrected visual acuity, inflammation of the anterior chamber (anterior chamber cells, hypopyon, the presence of fibrin, active posterior keratic precipitates and iris nodules), intraocular pressure, inflammation of the vitreous cavity (vitreous haze, snowballs and snowbanks), central macular edema, inflammation of the posterior pole (the presence and number of choroidal/retinal lesions, vascular inflammation and papillitis), and global assessment from both (patient and physician). From all the variables studied in the multivariate model, anterior chamber cell grade, vitreous haze, central macular edema, inflammatory vessel sheathing, papillitis, choroidal/retinal lesions and patient evaluation were included in UVEDAI. UVEDAI is an index designed to assess the global ocular inflammatory activity in patients with uveitis. It might prove worthwhile to motorize the activity of this extraarticular manifestation of some rheumatic diseases.
Palabras clave
MESH
Adult | Aged | Female | Humans | Inflammation | Male | Middle Aged | Severity of Illness Index | Uveitis
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
- Nombre:
- DevelopmentOfAnActivity_2017.pdf
- Tamaño:
- 346.0Kb
- Formato:
- Descripción:
- Artículo principal