Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/13951
Título
Nonmotor symptom burden grading as predictor of cognitive impairment in Parkinson's disease
Autor(es)
Oikonomou, Panteleimon | van Wamelen, Daniel J | Weintraub, Daniel | Aarsland, Dag | Ffytche, Dominic | Martínez-Martín, Pablo ISCIII | Rodriguez-Blazquez, Carmen ISCIII | Leta, Valentina | Borley, Corinne | Sportelli, Carolina | Trivedi, Dhaval | Podlewska, Aleksandra M | Rukavina, Katarina | Rizos, Alexandra | Lazcano-Ocampo, Claudia | Ray Chaudhuri, Kallol
Fecha de publicación
2021-05
Cita
Brain Behav. 2021;11(5):e02086.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Background: Identifying predictors of incident cognitive impairment (CI), one of the most problematic long-term outcomes, in Parkinson's disease (PD) is highly relevant for personalized medicine and prognostic counseling. The Nonmotor Symptoms Scale (NMSS) provides a global clinical assessment of a range of NMS, reflecting NMS burden (NMSB), and thus may assist in the identification of an "at-risk" CI group based on overall NMSB cutoff scores. Methods: To investigate whether specific patterns of PD NMS profiles predict incident CI, we performed a retrospective longitudinal study on a convenience sample of 541 nondemented PD patients taking part in the Nonmotor Longitudinal International Study (NILS) cohort, with Mini-Mental State Examination (MMSE), NMSS, and Scales for Outcomes in PD Motor Scale (SCOPA Motor) scores at baseline and last follow-up (mean 3.2 years) being available. Results: PD patients with incident CI (i.e., MMSE score ≤ 25) at last follow-up (n = 107) had severe overall NMSB level, significantly worse NMSS hallucinations/perceptual problems and higher NMSS attention/memory scores at baseline. Patients with CI also were older and with more advanced disease, but with no differences in disease duration, dopamine replacement therapy, sex, and comorbid depression, anxiety, and sleep disorders. Conclusions: Our findings suggest that a comprehensive baseline measure of NMS and in particular hallucinations and perceptual problems assessed with a validated single instrument can be used to predict incident CI in PD. This approach provides a simple, holistic strategy to predict future CI in this population.
Palabras clave
MMSE | Nonmotor symptom burden grading | Nonmotor symptoms | Parkinson's disease | Cognitive impairment
Versión en línea
DOI
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