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dc.contributor.authorOikonomou, Panteleimon
dc.contributor.authorvan Wamelen, Daniel J
dc.contributor.authorWeintraub, Daniel
dc.contributor.authorAarsland, Dag
dc.contributor.authorFfytche, Dominic
dc.contributor.authorMartinez-Martin, Pablo
dc.contributor.authorRodriguez-Blazquez, Carmen 
dc.contributor.authorLeta, Valentina
dc.contributor.authorBorley, Corinne
dc.contributor.authorSportelli, Carolina
dc.contributor.authorTrivedi, Dhaval
dc.contributor.authorPodlewska, Aleksandra M
dc.contributor.authorRukavina, Katarina
dc.contributor.authorRizos, Alexandra
dc.contributor.authorLazcano-Ocampo, Claudia
dc.contributor.authorRay Chaudhuri, Kallol
dc.identifier.citationBrain Behav. 2021;11(5):e02086.es_ES
dc.description.abstractBackground: Identifying predictors of incident cognitive impairment (CI), one of the most problematic long-term outcomes, in Parkinson's disease (PD) is highly relevant for personalized medicine and prognostic counseling. The Nonmotor Symptoms Scale (NMSS) provides a global clinical assessment of a range of NMS, reflecting NMS burden (NMSB), and thus may assist in the identification of an "at-risk" CI group based on overall NMSB cutoff scores. Methods: To investigate whether specific patterns of PD NMS profiles predict incident CI, we performed a retrospective longitudinal study on a convenience sample of 541 nondemented PD patients taking part in the Nonmotor Longitudinal International Study (NILS) cohort, with Mini-Mental State Examination (MMSE), NMSS, and Scales for Outcomes in PD Motor Scale (SCOPA Motor) scores at baseline and last follow-up (mean 3.2 years) being available. Results: PD patients with incident CI (i.e., MMSE score ≤ 25) at last follow-up (n = 107) had severe overall NMSB level, significantly worse NMSS hallucinations/perceptual problems and higher NMSS attention/memory scores at baseline. Patients with CI also were older and with more advanced disease, but with no differences in disease duration, dopamine replacement therapy, sex, and comorbid depression, anxiety, and sleep disorders. Conclusions: Our findings suggest that a comprehensive baseline measure of NMS and in particular hallucinations and perceptual problems assessed with a validated single instrument can be used to predict incident CI in PD. This approach provides a simple, holistic strategy to predict future CI in this population.es_ES
dc.description.sponsorshipAlbert‐Ludwigs‐Universität Freiburg: D637es_ES
dc.publisherWiley es_ES
dc.subjectNonmotor symptom burden gradinges_ES
dc.subjectNonmotor symptomses_ES
dc.subjectParkinson's diseasees_ES
dc.subjectCognitive impairmentes_ES
dc.titleNonmotor symptom burden grading as predictor of cognitive impairment in Parkinson's diseasees_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderUniversity of Freiburg (Alemania)es_ES
dc.identifier.journalBrain and Behaviores_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.rights.accessRightsopen accesses_ES

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