Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/13823
Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers
Emerg Microbes Infect. 2021 Dec;10(1):493-496.
We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.
Genetic Predisposition to Disease | Health Personnel | Polymorphism, Single Nucleotide | SARS-CoV-2 | Adult | Aged | Aged, 80 and over | Angiotensin-Converting Enzyme 2 | COVID-19 | Female | Humans | Male | Middle Aged
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