2024-03-29T07:29:00Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/138232022-11-03T14:42:30Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2060com_20.500.12105_2052col_20.500.12105_16988col_20.500.12105_2061
Repisalud
author
Martínez-Sanz, Javier
author
Jiménez, Daniel
author
Martínez-Campelo, Laura
author
Cruz, Raquel
author
Vizcarra, Pilar
author
Sánchez-Conde, Matilde
author
Ron, Raquel
author
Rodríguez, Mario
author
Herrera, Sabina
author
Moreno, Santiago
author
Lopez-Huertas, Maria Rosa
author
Serrano-Villar, Sergio
funder
Instituto de Salud Carlos III
funder
Merck, Sharp & Dohme
2022-03-25T12:56:44Z
2022-03-25T12:56:44Z
2021-12
Emerg Microbes Infect. 2021 Dec;10(1):493-496.
http://hdl.handle.net/20.500.12105/13823
33704002
10.1080/22221751.2021.1902755
2222-1751
Emerging Microbes & Infections
We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.
eng
COVID-19
SARS-CoV-2
Genetic variants
Single-nucleotide polymorphism
Susceptibility
Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/13823/1/RoleOfACE2Genetic_2021.pdf
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RoleOfACE2Genetic_2021.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/13823/4/RoleOfACE2Genetic_2021.pdf.txt
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RoleOfACE2Genetic_2021.pdf.txt