Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/13724
Título
Pre-existing Hemagglutinin Stalk Antibodies Correlate with Protection of Lower Respiratory Symptoms in Flu-Infected Transplant Patients
Autor(es)
Aydillo, Teresa | Escalera, Alba | Strohmeier, Shirin | Aslam, Sadaf | Sanchez-Cespedes, Javier | Ayllon, Juan | Roca-Oporto, Cristina | Perez-Romero, Pilar ISCIII | Montejo, Miguel | Gavalda, Joan | Munoz, Patricia | Lopez-Medrano, Francisco | Carratala, Jordi | Krammer, Florian | García-Sastre, Adolfo | Cordero, Elisa
Fecha de publicación
2020-11-17
Cita
Cell Rep Med. 2020 Nov 3;1(8):100130.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Hemagglutination-inhibitory antibodies are usually highly strain specific with little effect on infection with drifted or shifted strains. The significance of broadly cross-reactive non-HAI anti-influenza antibodies against conserved domains of virus glycoproteins, such as the hemagglutinin (HA) stalk, is of great interest. We characterize a cohort of 40 H1N1pmd09 influenza-infected patients and identify lower respiratory symptoms (LRSs) as a predictor for development of pneumonia. A binomial logistic regression of log10 pre-existing antibody values shows that the probability of LRS occurrence decreased with increased anti-HA full-length and stalk antibody ELISA titers. However, a multilevel logistic regression model adjusted by other potential serocorrelates demonstrates that only antibodies directed against the stalk of HA correlate with protection from lower respiratory infection, limiting disease progression. Our predictive model indicates that a threshold of protective immunity based on broadly cross-reactive HA stalk antibodies could be feasible.
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Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón (Madrid)
- Investigación > IIS > IDIBELL - Instituto de Investigación Biomédica de Bellvitge (Cataluña)
- Investigación > IIS > IBIS - Instituto de Biomedicina de Sevilla (Andalucía)
- Investigación > IIS > i+12 - Instituto de Investigación Hospital 12 de Octubre (Madrid)
- Investigación > ISCIII > Centro Nacional de Microbiología (CNM) > ISCIII - Artículos