Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/13429
microRNA Fine-Tuning of the Germinal Center Response.
Front Immunol. 2021; 12:660450
Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. These reactions are tightly controlled by a variety of mechanisms, including the post-transcriptional control of gene expression by microRNAs (miRNAs). Through the development of animal models with B cell-specific modified miRNA expression, we have contributed to the understanding of the role of miRNAs in the regulation of GC responses and in B cell neoplasia. Here, we review recent advances in the understanding of the role of miRNAs in the regulation of B cell and T follicular helper physiology during the GC response and in the diseases associated to GC response dysregulation.
Animals | B-Lymphocytes | Cell Differentiation | Gene Expression Regulation | Germinal Center | Humans | Mice | MicroRNAs
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