2024-03-29T07:34:44Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/134292022-11-07T14:10:33Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2145com_20.500.12105_2144col_20.500.12105_16938col_20.500.12105_2146
Repisalud
author
Fuertes, Teresa
author
Salgado, Irene
author
de Yebenes, Virginia G
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Complutense University of Madrid (España)
funder
Ministerio de Educación y Formación Profesional (España)
2021-10-15T06:08:24Z
2021-10-15T06:08:24Z
2021-04
Front Immunol. 2021; 12:660450
1664-3224
http://hdl.handle.net/20.500.12105/13429
33953721
10.3389/fimmu.2021.660450
Frontiers in immunology
Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. These reactions are tightly controlled by a variety of mechanisms, including the post-transcriptional control of gene expression by microRNAs (miRNAs). Through the development of animal models with B cell-specific modified miRNA expression, we have contributed to the understanding of the role of miRNAs in the regulation of GC responses and in B cell neoplasia. Here, we review recent advances in the understanding of the role of miRNAs in the regulation of B cell and T follicular helper physiology during the GC response and in the diseases associated to GC response dysregulation.
eng
microRNA Fine-Tuning of the Germinal Center Response.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/13429/1/microRNAFine-Tuningof_2021.pdf
File
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microRNAFine-Tuningof_2021.pdf
URL
https://repisalud.isciii.es/bitstream/20.500.12105/13429/4/microRNAFine-Tuningof_2021.pdf.txt
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microRNAFine-Tuningof_2021.pdf.txt