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dc.contributor.authorFuertes, Teresa
dc.contributor.authorSalgado, Irene
dc.contributor.authorde Yebenes, Virginia G 
dc.date.accessioned2021-10-15T06:08:24Z
dc.date.available2021-10-15T06:08:24Z
dc.date.issued2021-04
dc.identifier.citationFront Immunol. 2021; 12:660450es_ES
dc.identifier.issn1664-3224es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13429
dc.description.abstractGerminal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. These reactions are tightly controlled by a variety of mechanisms, including the post-transcriptional control of gene expression by microRNAs (miRNAs). Through the development of animal models with B cell-specific modified miRNA expression, we have contributed to the understanding of the role of miRNAs in the regulation of GC responses and in B cell neoplasia. Here, we review recent advances in the understanding of the role of miRNAs in the regulation of B cell and T follicular helper physiology during the GC response and in the diseases associated to GC response dysregulation.es_ES
dc.description.sponsorshipOur work is supported by the Spanish Ministerio de Ciencia e Innovación (PID2019-107551RB-I00). TF is supported by a PhD fellowship from the Spanish Ministerio de Ciencia, Innovacion y Universidades (BES-2017-079759), VY by funding from the Universidad Complutense de Madrid, and IS by a student research grant from the Ministerio de Educación y Formación Profesional.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshB-Lymphocytes es_ES
dc.subject.meshCell Differentiation es_ES
dc.subject.meshGene Expression Regulation es_ES
dc.subject.meshGerminal Center es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMice es_ES
dc.subject.meshMicroRNAs es_ES
dc.titlemicroRNA Fine-Tuning of the Germinal Center Response.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33953721es_ES
dc.format.volume12es_ES
dc.format.page660450es_ES
dc.identifier.doi10.3389/fimmu.2021.660450es_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España) 
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderComplutense University of Madrid (España) 
dc.contributor.funderMinisterio de Educación y Formación Profesional (España) 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2021.660450es_ES
dc.identifier.journalFrontiers in immunologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Biología de linfocitos Bes_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/BES-2017-079759es_ES


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