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dc.contributor.author | Fuertes, Teresa | |
dc.contributor.author | Salgado, Irene | |
dc.contributor.author | de Yebenes, Virginia G | |
dc.date.accessioned | 2021-10-15T06:08:24Z | |
dc.date.available | 2021-10-15T06:08:24Z | |
dc.date.issued | 2021-04 | |
dc.identifier.citation | Front Immunol. 2021; 12:660450 | es_ES |
dc.identifier.issn | 1664-3224 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/13429 | |
dc.description.abstract | Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. These reactions are tightly controlled by a variety of mechanisms, including the post-transcriptional control of gene expression by microRNAs (miRNAs). Through the development of animal models with B cell-specific modified miRNA expression, we have contributed to the understanding of the role of miRNAs in the regulation of GC responses and in B cell neoplasia. Here, we review recent advances in the understanding of the role of miRNAs in the regulation of B cell and T follicular helper physiology during the GC response and in the diseases associated to GC response dysregulation. | es_ES |
dc.description.sponsorship | Our work is supported by the Spanish Ministerio de Ciencia e Innovación (PID2019-107551RB-I00). TF is supported by a PhD fellowship from the Spanish Ministerio de Ciencia, Innovacion y Universidades (BES-2017-079759), VY by funding from the Universidad Complutense de Madrid, and IS by a student research grant from the Ministerio de Educación y Formación Profesional. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | B-Lymphocytes | es_ES |
dc.subject.mesh | Cell Differentiation | es_ES |
dc.subject.mesh | Gene Expression Regulation | es_ES |
dc.subject.mesh | Germinal Center | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | MicroRNAs | es_ES |
dc.title | microRNA Fine-Tuning of the Germinal Center Response. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 33953721 | es_ES |
dc.format.volume | 12 | es_ES |
dc.format.page | 660450 | es_ES |
dc.identifier.doi | 10.3389/fimmu.2021.660450 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Complutense University of Madrid (España) | |
dc.contributor.funder | Ministerio de Educación y Formación Profesional (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fimmu.2021.660450 | es_ES |
dc.identifier.journal | Frontiers in immunology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Biología de linfocitos B | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/BES-2017-079759 | es_ES |