Publication: Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach.
Loading...
Identifiers
Publication date
2021-04-22
Authors
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Media
Metrics
Export
Abstract
Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. Ascaris suum and Trichuris muris have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. In the case of hookworms, despite most of the murine models do not fully reproduce the life cycle of Necator americanus, their proteomic similarity makes them highly suitable for the development of novel vaccine candidates and for the study of hookworm biological features. Furthermore, these models have been helpful in elucidating some basic aspects of our immune system, and are currently being used by numerous researchers to develop novel molecules with immunomodulatory proteins. Herein we review the similarities in the proteomic composition between Nippostrongylus brasiliensis, Heligmosomoides polygyrus bakeri and Trichuris muris and their respective human counterpart with a focus on the vaccine candidates and immunomodulatory proteins being currently studied.
Description
MeSH Terms
DeCS Terms
Bibliographic citation
Front Cell Infect Microbiol. 2021 Apr 22;11:639573.