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dc.contributor.authorMontaño, Karen J
dc.contributor.authorCuéllar, Carmen
dc.contributor.authorSotillo, Javier 
dc.date.accessioned2021-09-13T10:01:10Z
dc.date.available2021-09-13T10:01:10Z
dc.date.issued2021-04-22
dc.identifier.citationFront Cell Infect Microbiol. 2021 Apr 22;11:639573.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13379
dc.description.abstractSoil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. Ascaris suum and Trichuris muris have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. In the case of hookworms, despite most of the murine models do not fully reproduce the life cycle of Necator americanus, their proteomic similarity makes them highly suitable for the development of novel vaccine candidates and for the study of hookworm biological features. Furthermore, these models have been helpful in elucidating some basic aspects of our immune system, and are currently being used by numerous researchers to develop novel molecules with immunomodulatory proteins. Herein we review the similarities in the proteomic composition between Nippostrongylus brasiliensis, Heligmosomoides polygyrus bakeri and Trichuris muris and their respective human counterpart with a focus on the vaccine candidates and immunomodulatory proteins being currently studied.es_ES
dc.description.sponsorshipJS is a Miguel Servet Fellow funded by Instituto de Salud Carlos III (CP17III/00002, MPY 406/18 and MPY 504/19).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHeligmosomoides polygyruses_ES
dc.subjectNippostrongylus brasiliensises_ES
dc.subjectTrichuris murises_ES
dc.subjectHost-parasite interactionses_ES
dc.subjectImmunomodulationes_ES
dc.subjectProteomicses_ES
dc.subjectSoil-transmitted helminths (STHs)es_ES
dc.subjectVaccineses_ES
dc.titleRodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33968800es_ES
dc.format.volume11es_ES
dc.format.page639573es_ES
dc.identifier.doi10.3389/fcimb.2021.639573es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Comisión Europea 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2235-2988es_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fcimb.2021.639573es_ES
dc.identifier.journalFrontiers In Cellular And Infection Microbiologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/CP17III/00002es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/MPY 406/18es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/MPY 504/19es_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional