Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/13340
Título
CSVS, a crowdsourcing database of the Spanish population genetic variability.
Autor(es)
Peña-Chilet, María | Roldán, Gema | Perez-Florido, Javier | Ortuño, Francisco M | Carmona, Rosario | Aquino, Virginia ISCIII | Lopez-Lopez, Daniel | Loucera, Carlos | Fernandez-Rueda, Jose L | Gallego, Asunción | García-Garcia, Francisco | Pita, Guillermo | Gonzalez Neira, Anna CNIO | Núñez-Torres, Rocío | Santoyo-López, Javier | Ayuso, Carmen | Minguez, Pablo | Avila-Fernandez, Almudena | Corton, Marta | Moreno-Pelayo, Miguel Ángel | Morin, Matías | Gallego-Martinez, Alvaro | Lopez-Escamez, Jose A | Borrego, Salud | Antiñolo, Guillermo | Amigo, Jorge | Salgado-Garrido, Josefa | Pasalodos-Sanchez, Sara | Morte, Beatriz | Carracedo, Ángel | Alonso, Ángel | Dopazo, Joaquín
Fecha de publicación
2021-01-08
Cita
Nucleic Acids Res . 2021;49(D1):D1130-D1137.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The knowledge of the genetic variability of the local population is of utmost importance in personalized medicine and has been revealed as a critical factor for the discovery of new disease variants. Here, we present the Collaborative Spanish Variability Server (CSVS), which currently contains more than 2000 genomes and exomes of unrelated Spanish individuals. This database has been generated in a collaborative crowdsourcing effort collecting sequencing data produced by local genomic projects and for other purposes. Sequences have been grouped by ICD10 upper categories. A web interface allows querying the database removing one or more ICD10 categories. In this way, aggregated counts of allele frequencies of the pseudo-control Spanish population can be obtained for diseases belonging to the category removed. Interestingly, in addition to pseudo-control studies, some population studies can be made, as, for example, prevalence of pharmacogenomic variants, etc. In addition, this genomic data has been used to define the first Spanish Genome Reference Panel (SGRP1.0) for imputation. This is the first local repository of variability entirely produced by a crowdsourcing effort and constitutes an example for future initiatives to characterize local variability worldwide. CSVS is also part of the GA4GH Beacon network. CSVS can be accessed at: http://csvs.babelomics.org/.
MESH
Crowdsourcing | Databases, Genetic | Genome, Human | Software | Alleles | Chromosome Mapping | Exome | Gene Frequency | Genetic Variation | Genetics, Population | Genomics | Humans | Internet | Precision Medicine | Spain
Versión en línea
DOI
Aparece en las colecciones
- Investigación > CNIO > Grupos de investigación
- Investigación > IIS > IBIS - Instituto de Biomedicina de Sevilla (Andalucía)
- Investigación > IIS > ibs.GRANADA - Instituto de Investigación Biosanitaria de Granada (Andalucía)
- Investigación > IIS > IDIS - Instituto de Investigación Sanitaria de Santiago de Compostela (Galicia)
- Investigación > IIS > IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
- Investigación > IIS > IIS-FJD - Instituto de Investigación Sanitaria Fundación Jiménez Díaz (Madrid)
- Investigación > IIS > IRYCIS - Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)
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- CSVSacrowdsourcingdatabase_2021.pdf
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- Artículo principal
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- tablas