Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/13322
Título
Gαq activation modulates autophagy by promoting mTORC1 signaling.
Autor(es)
Fecha de publicación
2021-07-27
Cita
Nat Commun.2021;12(1):4540.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The mTORC1 node plays a major role in autophagy modulation. We report a role of the ubiquitous Gαq subunit, a known transducer of plasma membrane G protein-coupled receptors signaling, as a core modulator of mTORC1 and autophagy. Cells lacking Gαq/11 display higher basal autophagy, enhanced autophagy induction upon different types of nutrient stress along with a decreased mTORC1 activation status. They are also unable to reactivate mTORC1 and thus inactivate ongoing autophagy upon nutrient recovery. Conversely, stimulation of Gαq/11 promotes sustained mTORC1 pathway activation and reversion of autophagy promoted by serum or amino acids removal. Gαq is present in autophagic compartments and lysosomes and is part of the mTORC1 multi-molecular complex, contributing to its assembly and activation via its nutrient status-sensitive interaction with p62, which displays features of a Gαq effector. Gαq emerges as a central regulator of the autophagy machinery required to maintain cellular homeostasis upon nutrient fluctuations.
MESH
Autophagy | Signal Transduction | Animals | CHO Cells | Cricetulus | Fibroblasts | GTP-Binding Protein alpha Subunits, Gq-G11 | HEK293 Cells | Humans | Lysosomes | Male | Mechanistic Target of Rapamycin Complex 1 | Mice | Models, Biological | Phenotype | Protein Binding | Protein Domains | Rats, Wistar | Regulatory-Associated Protein of mTOR | Sequestosome-1 Protein
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