Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/12687
Título
Sarcoma treatment in the era of molecular medicine.
Autor(es)
Grünewald, Thomas Gp | Alonso, Marta | Avnet, Sofia | Banito, Ana | Burdach, Stefan | Cidre-Aranaz, Florencia | Di Pompo, Gemma | Distel, Martin | Dorado-Garcia, Heathcliff | Garcia-Castro, Javier ISCIII | Gonzalez-Gonzalez, Laura ISCIII | Grigoriadis, Agamemnon E | Kasan, Merve | Koelsche, Christian | Krumbholz, Manuela | Lecanda, Fernando | Lemma, Silvia | Longo, Dario L | Madrigal-Esquivel, Claudia | Morales-Molina, Alvaro ISCIII | Musa, Julian | Ohmura, Shunya | Ory, Benjamin | Pereira-Silva, Miguel | Perut, Francesca | Rodriguez, Rene | Seeling, Carolin | Al Shaaili, Nada | Shaabani, Shabnam | Shiavone, Kristina | Sinha, Snehadri | Tomazou, Eleni M | Trautmann, Marcel | Vela, Maria | Versleijen-Jonkers, Yvonne Mh | Visgauss, Julia | Zalacain, Marta | Schober, Sebastian J | Lissat, Andrej | English, William R | Baldini, Nicola | Heymann, Dominique
Fecha de publicación
2020
Cita
EMBO Mol Med . 2020 Nov 6;12(11):e11131.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.
Palabras clave
Descripción
Factor de impacto: 12,137 Q1
Versión en línea
DOI
Aparece en las colecciones
- Investigación > ISCIII > Instituto de Investigación de Enfermedades Raras (IIER)
- Investigación > IIS > ISPA - Instituto de Investigación Sanitaria del Principado de Asturias (Asturias)
- Eventos Científicos > ISCIII > Programa de Mentores del ISCIII > Publicaciones de los mentorizados
- Investigación > IIS > IdiPAZ - Instituto de Investigación Sanitaria Hospital La Paz (Madrid)