2024-03-28T15:52:27Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/126872022-07-15T06:32:04Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_14556com_20.500.12105_2337com_20.500.12105_2336com_20.500.12105_2102com_20.500.12105_2052col_20.500.12105_16990col_20.500.12105_16963col_20.500.12105_14558col_20.500.12105_2103
Repisalud
author
Grünewald, Thomas Gp
author
Alonso, Marta
author
Avnet, Sofia
author
Banito, Ana
author
Burdach, Stefan
author
Cidre-Aranaz, Florencia
author
Di Pompo, Gemma
author
Distel, Martin
author
Dorado-Garcia, Heathcliff
author
Garcia-Castro, Javier
author
Gonzalez-Gonzalez, Laura
author
Grigoriadis, Agamemnon E
author
Kasan, Merve
author
Koelsche, Christian
author
Krumbholz, Manuela
author
Lecanda, Fernando
author
Lemma, Silvia
author
Longo, Dario L
author
Madrigal-Esquivel, Claudia
author
Morales-Molina, Alvaro
author
Musa, Julian
author
Ohmura, Shunya
author
Ory, Benjamin
author
Pereira-Silva, Miguel
author
Perut, Francesca
author
Rodriguez, Rene
author
Seeling, Carolin
author
Al Shaaili, Nada
author
Shaabani, Shabnam
author
Shiavone, Kristina
author
Sinha, Snehadri
author
Tomazou, Eleni M
author
Trautmann, Marcel
author
Vela, Maria
author
Versleijen-Jonkers, Yvonne Mh
author
Visgauss, Julia
author
Zalacain, Marta
author
Schober, Sebastian J
author
Lissat, Andrej
author
English, William R
author
Baldini, Nicola
author
Heymann, Dominique
2021-04-19T15:24:03Z
2021-04-19T15:24:03Z
2020
EMBO Mol Med . 2020 Nov 6;12(11):e11131.
http://hdl.handle.net/20.500.12105/12687
33047515
10.15252/emmm.201911131
1757-4684
EMBO molecular medicine
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.
eng
Bone sarcoma
Molecular diagnostics
Molecular medicine
Soft tissue sarcoma
Targeted therapy
Sarcoma treatment in the era of molecular medicine.
journal article
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URL
https://repisalud.isciii.es/bitstream/20.500.12105/12687/1/SarcomaTreatmentInThe_2020.pdf
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https://repisalud.isciii.es/bitstream/20.500.12105/12687/4/SarcomaTreatmentInThe_2020.pdf.txt
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