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dc.contributor.authorKöster, Pamela Carolina 
dc.contributor.authorMalheiros, Antonio F
dc.contributor.authorShaw, Jeffrey J
dc.contributor.authorBalasegaram, Sooria
dc.contributor.authorPrendergast, Alexander
dc.contributor.authorLucaccioni, Héloïse
dc.contributor.authorMoreira, Luciana Melhorança
dc.contributor.authorLemos, Larissa M S
dc.contributor.authorDashti, Alejandro 
dc.contributor.authorBailo-Barroso, Begoña 
dc.contributor.authorMarcili, Arlei
dc.contributor.authorSousa Soares, Herbert
dc.contributor.authorGennari, Solange Maria
dc.contributor.authorCalero-Bernal, Rafael
dc.contributor.authorGonzález-Barrio, David 
dc.contributor.authorCarmena, David 
dc.date.accessioned2021-04-12T20:48:22Z
dc.date.available2021-04-12T20:48:22Z
dc.date.issued2021-02-14
dc.identifier.citationPathogens . 2021 Feb 14;10(2):206.es_ES
dc.identifier.issn2076-0817es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12615
dc.description.abstractLittle information is available on the occurrence and genetic variability of the diarrhoea-causing enteric protozoan parasite Giardia duodenalis in indigenous communities in Brazil. This cross-sectional epidemiological survey describes the frequency, genotypes, and risk associations for this pathogen in Tapirapé people (Brazilian Amazon) at four sampling campaigns during 2008-2009. Microscopy was used as a screening test, and molecular (PCR and Sanger sequencing) assays targeting the small subunit ribosomal RNA, the glutamate dehydrogenase, the beta-giardin, and the triosephosphate isomerase genes as confirmatory/genotyping methods. Associations between G. duodenalis and sociodemographic and clinical variables were investigated using Chi-squared test and univariable/multivariable logistic regression models. Overall, 574 individuals belonging to six tribes participated in the study, with G. duodenalis prevalence rates varying from 13.5-21.7%. The infection was positively linked to younger age and tribe. Infected children <15 years old reported more frequent gastrointestinal symptoms compared to adults. Assemblage B accounted for three out of four G. duodenalis infections and showed a high genetic diversity. No association between assemblage and age or occurrence of diarrhoea was demonstrated. These data indicate that the most likely source of infection was anthropic and that different pathways (e.g., drinking water) may be involved in the transmission of the parasite.es_ES
dc.description.sponsorshipThis research was funded by the São Paulo State Research Support Foundation (FAFESP, Brazil), the National Health Foundation (FUNASA, Brazil), and the Mato Grosso State Research Support Foundation (FAPEMAT, Brazil), grant number 0839/2006. Additional funding was obtained from the Health Institute Carlos III (ISCIII), Ministry of Economy and Competitiveness (Spain), grant number PI16CIII/00024.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAmazones_ES
dc.subjectBraziles_ES
dc.subjectGiardiaes_ES
dc.subjectTapirapées_ES
dc.subjectasymptomatices_ES
dc.subjectcommunityes_ES
dc.subjectgenotypinges_ES
dc.subjectindigenouses_ES
dc.subjectrisk associationes_ES
dc.subjecttransmissiones_ES
dc.titleMultilocus Genotyping of Giardia duodenalis in Mostly Asymptomatic Indigenous People from the Tapirapé Tribe, Brazilian Amazon.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33672794es_ES
dc.format.volume10es_ES
dc.format.number2es_ES
dc.identifier.doi10.3390/pathogens10020206es_ES
dc.contributor.funderSão Paulo State Research Support Foundation (FAFESP, Brazil)es_ES
dc.contributor.funderNational Health Foundation (FUNASA, Brazil)es_ES
dc.contributor.funderMato Grosso State Research Support Foundation (FAPEMAT, Brazil)es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/pathogens10020206es_ES
dc.identifier.journalPathogens (Basel, Switzerland)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI16CIII/00024es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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