dc.contributor.author | Ruiz-de-León, María J | |
dc.contributor.author | Jimenez-Sousa, Maria Angeles | |
dc.contributor.author | Moreno, Santiago | |
dc.contributor.author | García, Marcial | |
dc.contributor.author | Gutiirrez-Rivas, Monica | |
dc.contributor.author | León, Agathe | |
dc.contributor.author | Montero-Alonso, Marta | |
dc.contributor.author | González-García, Juan | |
dc.contributor.author | Resino, Salvador | |
dc.contributor.author | Rallón, Norma | |
dc.contributor.author | Benito, José Miguel | |
dc.contributor.author | Vallejo, Alejandro | |
dc.contributor.author | ECRIS Network integrated in the Spanish AIDS Research Network | |
dc.contributor.author | Briz, Veronica | |
dc.contributor.author | Jimenez-Sousa, Maria Angeles | |
dc.contributor.author | Vazquez-Moron, Sonia | |
dc.contributor.author | Fernández, A | |
dc.contributor.author | García, P | |
dc.contributor.author | Pernas, Maria | |
dc.contributor.author | Casado, Concepcion | |
dc.contributor.author | López, C | |
dc.contributor.author | Capa, Laura | |
dc.contributor.author | Pérez, M | |
dc.contributor.author | Alcamí, José | |
dc.date.accessioned | 2021-03-27T15:02:59Z | |
dc.date.available | 2021-03-27T15:02:59Z | |
dc.date.issued | 2019-08 | |
dc.identifier.citation | J Microbiol Immunol Infect . 2019 Aug;52(4):667-671. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/12456 | |
dc.description.abstract | Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found. | es_ES |
dc.description.sponsorship | This work has been partially funded by the Spanish Health Institute Carlos III (ISCIII) and European Regional Development Fund, Spanish AIDS Research Network (RIS) with grant numbers RD16/0025/0001, RD12/0017/0031, RD16/0025/0013, and RD16/0002/0002. Research Grant Project, Spanish Health Research Fund (FIS, ISCIII) number PI14/00011. Miguel Servet Research Program, Spanish Health Institute Carlos III (ISCIII) CP14/00198 to NR. Spanish Health Research Fund (FIS, ISCIII) and IIS-FJD Intramural Research Scholarship co-funded grant number CP14/00198 to MG. Spanish Health Institute Carlos III (ISCIII) grant CD13/00013 to MAJS. Grant Research, Madrid Education, Youth and Sport Counseling number PEJ15/bio/tl-0064 to MJRL. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Exosomes | es_ES |
dc.subject | miRNAs | es_ES |
dc.subject | HIV-1 | es_ES |
dc.subject | Elite controllers | es_ES |
dc.subject | Immune activation | es_ES |
dc.subject | Soluble biomarkers | es_ES |
dc.subject.mesh | Exosomes | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Biomarkers | es_ES |
dc.subject.mesh | CD4 Lymphocyte Count | es_ES |
dc.subject.mesh | CD4-Positive T-Lymphocytes | es_ES |
dc.subject.mesh | Chemokine CCL2 | es_ES |
dc.subject.mesh | Cross-Sectional Studies | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | HIV Infections | es_ES |
dc.subject.mesh | HIV-1 | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | MicroRNAs | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Plasma | es_ES |
dc.title | Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 30193823 | es_ES |
dc.format.volume | 52 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | 667-671 | es_ES |
dc.identifier.doi | 10.1016/j.jmii.2018.07.007 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Red de Investigación Cooperativa en Investigación en Sida (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1995-9133 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.jmii.2018.07.007 | es_ES |
dc.identifier.journal | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD16/0025/0001 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0017/0031 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD16/0025/0013, | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD16/0002/0002 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CP14/00198 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CD13/00013 | es_ES |
dc.rights.accessRights | open access | es_ES |