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Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/12456
Title
Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count.
Author(s)
Ruiz-de-León, María J | Jimenez-Sousa, Maria Angeles ISCIII | Moreno, Santiago | García, Marcial | Gutiirrez-Rivas, Monica ISCIII | León, Agathe | Montero-Alonso, Marta | González-García, Juan | Resino, Salvador ISCIII | Rallón, Norma | Benito, José Miguel | Vallejo, Alejandro
Date issued
2019-08
Citation
J Microbiol Immunol Infect . 2019 Aug;52(4):667-671.
Language
Inglés
Abstract
Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = -0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found.
Subject
Exosomes | miRNAs | HIV-1 | Elite controllers | Immune activation | Soluble biomarkers
MESH
Exosomes | Adult | Biomarkers | CD4 Lymphocyte Count | CD4-Positive T-Lymphocytes | Chemokine CCL2 | Cross-Sectional Studies | Female | HIV Infections | HIV-1 | Humans | Male | MicroRNAs | Middle Aged | Plasma
Online version
https://doi.org/10.1016/j.jmii.2018.07.007
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