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dc.contributor.author | Cañada-Garcia, Javier Enrique | |
dc.contributor.author | Delgado, Elena | |
dc.contributor.author | Gil, Horacio | |
dc.contributor.author | Sanchez-Martinez, Monica | |
dc.contributor.author | Benito, Sonia | |
dc.contributor.author | Garcia-Bodas, Elena | |
dc.contributor.author | Gómez-González, Carmen | |
dc.contributor.author | Canut-Blasco, Andrés | |
dc.contributor.author | Portu-Zapirain, Joseba | |
dc.contributor.author | Sáez de Adana, Ester | |
dc.contributor.author | De la Peña, Mireia | |
dc.contributor.author | Ibarra, Sofía | |
dc.contributor.author | Cilla, Gustavo | |
dc.contributor.author | Iribarren, José Antonio | |
dc.contributor.author | Martínez-Sapiña, Ana | |
dc.contributor.author | Thomson, Michael M | |
dc.date.accessioned | 2021-02-26T19:15:49Z | |
dc.date.available | 2021-02-26T19:15:49Z | |
dc.date.issued | 2021-01-12 | |
dc.identifier.citation | Viruses. 2021 Jan 12;13(1):93. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/12025 | |
dc.description.abstract | The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms. Among CRFs, 11 derived from subtypes B and C have been identified in China, Brazil, and Italy. Here we identify a new HIV-1 CRF_BC in Northern Spain. Originally, a phylogenetic cluster of 15 viruses of subtype C in protease-reverse transcriptase was identified in an HIV-1 molecular surveillance study in Spain, most of them from individuals from the Basque Country and heterosexually transmitted. Analyses of near full-length genome sequences from six viruses from three cities revealed that they were BC recombinant with coincident mosaic structures different from known CRFs. This allowed the definition of a new HIV-1 CRF designated CRF108_BC, whose genome is predominantly of subtype C, with four short subtype B fragments. Phylogenetic analyses with database sequences supported a Brazilian ancestry of the parental subtype C strain. Coalescent Bayesian analyses estimated the most recent common ancestor of CRF108_BC in the city of Vitoria, Basque Country, around 2000. CRF108_BC is the first CRF_BC identified in Spain and the second in Europe, after CRF60_BC, both phylogenetically related to Brazilian subtype C strains. | es_ES |
dc.description.sponsorship | This work was funded through Acción Estratégica en Salud Intramural (AESI), Instituto de Salud Carlos III, projects “Estudios sobre vigilancia epidemiológica molecular del VIH- 1 en España,” PI16CIII/00033, and “Epidemiología molecular del VIH-1 en España y su utilidad para investigaciones biológicas y en vacunas”, PI19CIII/00042; Red de Investigación en SIDA (RIS), Instituto de Salud Carlos III, Subdirección General de Evaluación y Fondo Europeo de Desarrollo Regional (FEDER), Plan Nacional I + D + I, project RD16ISCIII/0002/0004; and scientific agreement with Osakidetza-Servicio Vasco de Salud, Government of Basque Country, MVI 1001/16. JC was supported by the Social European Fund through the Youth Employment Operational Program and the Youth Employment Initiative and by the Comunidad de Madrid. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | HIV-1 | es_ES |
dc.subject | HIV-1 genetic diversity | es_ES |
dc.subject | HIV-1 molecular epidemiology | es_ES |
dc.subject | HIV-1 phylogeny | es_ES |
dc.subject | Circulating recombinant form. | es_ES |
dc.title | Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain. | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 33445523 | es_ES |
dc.format.volume | 13 | es_ES |
dc.format.number | 1 | es_ES |
dc.identifier.doi | 10.3390/v13010093 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Red de Investigación Cooperativa en Investigación en Sida (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Basque Government (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1999-4915 | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/v13010093 | es_ES |
dc.identifier.journal | Viruses | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/ISCIII 2016 Modalidad Proyectos de Investigacion en Salud Intramurales. (2016)/PI16CIII/00033 | |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/Subprograma Estatal de Generación de Conocimiento/PI19-ISCIII Modalidad Proyectos de Investigacion en Salud Intramurales. (2019)/PI19CIII/00042 | |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/RD16ISCIII/0002/000 |