Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/12025
Identification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain.
Cañada, Javier ISCIII | Delgado, Elena ISCIII | Gil, Horacio ISCIII | Sanchez-Martinez, Monica ISCIII | Benito, Sonia ISCIII | Garcia-Bodas, Elena ISCIII | Gómez-González, Carmen | Canut-Blasco, Andrés | Portu-Zapirain, Joseba | Sáez de Adana, Ester | De la Peña, Mireia | Ibarra, Sofía | Cilla, Gustavo | Iribarren, José Antonio | Martínez-Sapiña, Ana | Thomson, Michael M ISCIII
Viruses . 2021 Jan 12;13(1):93.
The extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms. Among CRFs, 11 derived from subtypes B and C have been identified in China, Brazil, and Italy. Here we identify a new HIV-1 CRF_BC in Northern Spain. Originally, a phylogenetic cluster of 15 viruses of subtype C in protease-reverse transcriptase was identified in an HIV-1 molecular surveillance study in Spain, most of them from individuals from the Basque Country and heterosexually transmitted. Analyses of near full-length genome sequences from six viruses from three cities revealed that they were BC recombinant with coincident mosaic structures different from known CRFs. This allowed the definition of a new HIV-1 CRF designated CRF108_BC, whose genome is predominantly of subtype C, with four short subtype B fragments. Phylogenetic analyses with database sequences supported a Brazilian ancestry of the parental subtype C strain. Coalescent Bayesian analyses estimated the most recent common ancestor of CRF108_BC in the city of Vitoria, Basque Country, around 2000. CRF108_BC is the first CRF_BC identified in Spain and the second in Europe, after CRF60_BC, both phylogenetically related to Brazilian subtype C strains.
HIV-1 | HIV-1 genetic diversity | HIV-1 molecular epidemiology | HIV-1 phylogeny | circulating recombinant form.
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