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dc.contributor.authorVorkamp, Katrin
dc.contributor.authorCastaño, Argelia 
dc.contributor.authorAntignac, Jean-Philippe
dc.contributor.authorBoada, Luis D
dc.contributor.authorCequier, Enrique
dc.contributor.authorCovaci, Adrian
dc.contributor.authorEsteban-Lopez, Marta 
dc.contributor.authorHaug, Line S
dc.contributor.authorKasper-Sonnenberg, Monika
dc.contributor.authorKoch, Holger M
dc.contributor.authorPérez Luzardo, Octavio
dc.contributor.authorOsīte, Agnese
dc.contributor.authorRambaud, Loïc
dc.contributor.authorPinorini, Maria-Teresa
dc.contributor.authorSabbioni, Gabriele
dc.contributor.authorThomsen, Cathrine
dc.identifier.citationEnviron Int . 2021 Jan;146:106082.es_ES
dc.description.abstractThe major purpose of human biomonitoring is the mapping and assessment of human exposure to chemicals. The European initiative HBM4EU has prioritized seven substance groups and two metals relevant for human exposure: Phthalates and substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DINCH), bisphenols, per- and polyfluoroalkyl substances (PFASs), halogenated and organophosphorous flame retardants (HFRs and OPFRs), polycyclic aromatic hydrocarbons (PAHs), arylamines, cadmium and chromium. As a first step towards comparable European-wide data, the most suitable biomarkers, human matrices and analytical methods for each substance group or metal were selected from the scientific literature, based on a set of selection criteria. The biomarkers included parent compounds of PFASs and HFRs in serum, of bisphenols and arylamines in urine, metabolites of phthalates, DINCH, OPFRs and PAHs in urine as well as metals in blood and urine, with a preference to measure Cr in erythrocytes representing Cr (VI) exposure. High performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was the method of choice for bisphenols, PFASs, the HFR hexabromocyclododecane (HBCDD), phenolic HFRs as well as the metabolites of phthalates, DINCH, OPFRs and PAHs in urine. Gas chromatographic (GC) methods were selected for the remaining compounds, e.g. GC-low resolution MS with electron capture negative ionization (ECNI) for HFRs. Both GC-MS and LC-MS/MS were suitable for arylamines. New developments towards increased applications of GC-MS/MS may offer alternatives to GC-MS or LC-MS/MS approaches, e.g. for bisphenols. The metals were best determined by inductively coupled plasma (ICP)-MS, with the particular challenge of avoiding interferences in the Cd determination in urine. The evaluation process revealed research needs towards higher sensitivity and non-invasive sampling as well as a need for more stringent quality assurance/quality control applications and assessments.es_ES
dc.description.sponsorshipThis study was part of the HBM4EU project receiving funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032. The authors acknowledge Ana Gonzalez Antuña (University of Las Palmas de Gran Canaria), Lauma Buša (University of Latvia), Govindan Malarvannan and Celine Gys (University of Antwerp) for their help with the literature search.es_ES
dc.subjectFlame retardantses_ES
dc.subjectPer- and polyfluoroalkyl substanceses_ES
dc.titleBiomarkers, matrices and analytical methods targeting human exposure to chemicals selected for a European human biomonitoring initiative.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-SinObraDerivada 4.0 Internacional*
dc.contributor.funderEuropean Uniones_ES
dc.identifier.journalEnvironment internationales_ES
dc.rights.accessRightsopen accesses_ES

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Atribución-NoComercial-SinObraDerivada 4.0 Internacional
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