Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/11394
Detection of norovirus infections in Denmark, 2011-2018.
Epidemiol Infect . 2020 Feb 17;148:e52.
Norovirus (NoV) infections occur very frequently yet are rarely diagnosed. In Denmark, NoV infections are not under surveillance. We aimed to collect and describe existing laboratory-based NoV data. National NoV laboratory data were collected for 2011-2018, including information on patient identification number, age and sex, requesting physician, analysis date and result. We defined positive patient-episodes by using a 30-day time window and performed descriptive and time series analysis. Diagnostic methods used were assessed through a survey. We identified 15 809 patient-episodes (11%) out of 142 648 tested patients with an increasing trend, 9366 in 2011 vs. 32 260 in 2018. This corresponded with a gradual introduction of polymerase chain reaction analysis in laboratories. The highest positivity rate was in patients aged <5 years (15%) or >85 years (17%). There was a large difference in test performance over five Danish geographical regions and a marked seasonal variation with peaks from December to February. This is the first analysis of national NoV laboratory data in Denmark. A future laboratory-based surveillance system may benefit public health measures by describing trend, burden and severity of seasons and possibly pinpoint hospital outbreaks.
Epidemiology | Norwalk agent and related viruses | hospital-acquired (nosocomial) infections | norovirus | surveillance
Caliciviridae Infections | Disease Outbreaks | Adolescent | Adult | Aged | Aged, 80 and over | Child | Child, Preschool | Denmark | Female | Humans | Infant | Infant, Newborn | Male | Middle Aged | Seasons | Young Adult
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