Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/11357
Bactericidal synergism between antibiotics and phage endolysin Cpl-711 to kill multidrug-resistant pneumococcus.
Letrado, Patricia | Corsini, Bruno ISCIII | Díez-Martínez, Roberto | Bustamante, Noemí | Yuste, Jose Enrique ISCIII | García, Pedro
Future Microbiol . 2018 Sep;13(11):1215-1223.
To test the synergistic effect of Cpl-711 endolysin and antibiotics for antipneumococcal activity. A combination of Cpl-711 and different antibiotics (amoxicillin, cefotaxime, levofloxacin and vancomycin) was tested in a checkerboard assay against several multidrug-resistant Streptococcus pneumoniae strains. Mouse and zebrafish models of pneumococcal sepsis were used to confirm the in vitro data. The activity of Cpl-711 combined with amoxicillin or cefotaxime was synergistic in the bactericidal effect against a serotype 23F multiresistant clinical isolate of S. pneumoniae. Synergy between Cpl-711 and cefotaxime was validated using both mouse and zebrafish models. Combination of Cpl-711 and cefotaxime may help in the treatment of diseases caused by multiresistant pneumococcal strains.
Streptococcus pneumoniae | antibiotic multidrug-resistant | endolysin | mouse model | synergy | zebrafish model
Drug Resistance, Multiple, Bacterial | Animals | Anti-Bacterial Agents | Cefotaxime | Disease Models, Animal | Drug Synergism | Female | Mice | Mice, Inbred BALB C | Muramidase | Pneumococcal Infections | Recombinant Fusion Proteins | Sepsis | Streptococcus Phages | Streptococcus pneumoniae | Zebrafish
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