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dc.contributor.author | Letrado, Patricia | |
dc.contributor.author | Corsini, Bruno | |
dc.contributor.author | Díez-Martínez, Roberto | |
dc.contributor.author | Bustamante, Noemí | |
dc.contributor.author | Yuste, Jose Enrique | |
dc.contributor.author | García, Pedro | |
dc.date.accessioned | 2020-11-17T13:24:56Z | |
dc.date.available | 2020-11-17T13:24:56Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Future Microbiol . 2018 Sep;13(11):1215-1223. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/11357 | |
dc.description.abstract | To test the synergistic effect of Cpl-711 endolysin and antibiotics for antipneumococcal activity. A combination of Cpl-711 and different antibiotics (amoxicillin, cefotaxime, levofloxacin and vancomycin) was tested in a checkerboard assay against several multidrug-resistant Streptococcus pneumoniae strains. Mouse and zebrafish models of pneumococcal sepsis were used to confirm the in vitro data. The activity of Cpl-711 combined with amoxicillin or cefotaxime was synergistic in the bactericidal effect against a serotype 23F multiresistant clinical isolate of S. pneumoniae. Synergy between Cpl-711 and cefotaxime was validated using both mouse and zebrafish models. Combination of Cpl-711 and cefotaxime may help in the treatment of diseases caused by multiresistant pneumococcal strains. | es_ES |
dc.description.sponsorship | This research was supported by grants from the Ministerio de Economía y Competitividad (MINECO) to P García (SAF2017-88664) and JE Yuste (SAF2017-83388). Additional funding was provided by the CIBER de Enfermedades Respiratorias (CIBERES), an initiative of the Instituto de Salud Carlos III (ISCIII). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Future Medicine | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Streptococcus pneumoniae | es_ES |
dc.subject | antibiotic multidrug-resistant | es_ES |
dc.subject | endolysin | es_ES |
dc.subject | mouse model | es_ES |
dc.subject | synergy | es_ES |
dc.subject | zebrafish model | es_ES |
dc.subject.mesh | Drug Resistance, Multiple, Bacterial | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Anti-Bacterial Agents | es_ES |
dc.subject.mesh | Cefotaxime | es_ES |
dc.subject.mesh | Disease Models, Animal | es_ES |
dc.subject.mesh | Drug Synergism | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Mice, Inbred BALB C | es_ES |
dc.subject.mesh | Muramidase | es_ES |
dc.subject.mesh | Pneumococcal Infections | es_ES |
dc.subject.mesh | Recombinant Fusion Proteins | es_ES |
dc.subject.mesh | Sepsis | es_ES |
dc.subject.mesh | Streptococcus Phages | es_ES |
dc.subject.mesh | Streptococcus pneumoniae | es_ES |
dc.subject.mesh | Zebrafish | es_ES |
dc.title | Bactericidal synergism between antibiotics and phage endolysin Cpl-711 to kill multidrug-resistant pneumococcus. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 30238774 | es_ES |
dc.format.volume | 13 | es_ES |
dc.format.page | 1215-1223 | es_ES |
dc.identifier.doi | 10.2217/fmb-2018-0077 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Centro de Investigación Biomedica en Red - CIBER | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1746-0921 | |
dc.relation.publisherversion | https://doi.org/10.2217/fmb-2018-0077 | es_ES |
dc.identifier.journal | Future microbiology | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2017-88664 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2017-83388 | es_ES |
dc.rights.accessRights | open access | es_ES |