Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/11240
Título
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.
Autor(es)
Bosch, Marta | Sanchez-Alvarez, Miguel CNIC | Fajardo, Alba | Kapetanovic, Ronan | Steiner, Bernhard | Dutra, Filipe | Moreira, Luciana | Lopez, Juan Antonio CNIC | Campo | Marí, Montserrat | Morales-Paytuví, Frederic | Tort, Olivia | Gubern, Albert | Templin, Rachel M | Curson, James E B | Martel, Nick | Català, Cristina | Lozano, Francisco | Tebar, Francesc | Enrich, Carlos | Vazquez, Jesus CNIC | del Pozo, Miguel Angel CNIC | Sweet, Matthew J | Bozza, Patricia T | Gross, Steven P | Parton, Robert G | Pol, Albert
Fecha de publicación
2020-10
Cita
Science. 2020; 370(6514):eaay8085
Idioma
Inglés
Tipo de documento
journal article
Resumen
Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection.
MESH
Immunity, Innate | Animals | Antimicrobial Cationic Peptides | Bacteria | Fatty Acids | GTP Phosphohydrolases | HEK293 Cells | Host-Pathogen Interactions | Humans | Lipid Droplets | Lipopolysaccharides | Macrophages | Male | Mice | Mice, Inbred C57BL | Mitochondria
Versión en línea
DOI
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