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dc.contributor.authorBosch, Marta
dc.contributor.authorSanchez-Alvarez, Miguel 
dc.contributor.authorFajardo, Alba
dc.contributor.authorKapetanovic, Ronan
dc.contributor.authorSteiner, Bernhard
dc.contributor.authorDutra, Filipe
dc.contributor.authorMoreira, Luciana
dc.contributor.authorLopez, Juan Antonio 
dc.contributor.authorCampo
dc.contributor.authorMarí, Montserrat
dc.contributor.authorMorales-Paytuví, Frederic
dc.contributor.authorTort, Olivia
dc.contributor.authorGubern, Albert
dc.contributor.authorTemplin, Rachel M
dc.contributor.authorCurson, James E B
dc.contributor.authorMartel, Nick
dc.contributor.authorCatalà, Cristina
dc.contributor.authorLozano, Francisco
dc.contributor.authorTebar, Francesc
dc.contributor.authorEnrich, Carlos
dc.contributor.authorVazquez, Jesus 
dc.contributor.authordel Pozo, Miguel Angel 
dc.contributor.authorSweet, Matthew J
dc.contributor.authorBozza, Patricia T
dc.contributor.authorGross, Steven P
dc.contributor.authorParton, Robert G
dc.contributor.authorPol, Albert
dc.date.accessioned2020-10-28T12:31:27Z
dc.date.available2020-10-28T12:31:27Z
dc.date.issued2020-10
dc.identifier.citationScience. 2020; 370(6514):eaay8085es_ES
dc.identifier.issn0036-8075
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11240
dc.description.abstractLipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Association for the Advancement of Sciencees_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshImmunity, Innate es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshAntimicrobial Cationic Peptides es_ES
dc.subject.meshBacteria es_ES
dc.subject.meshFatty Acids es_ES
dc.subject.meshGTP Phosphohydrolases es_ES
dc.subject.meshHEK293 Cells es_ES
dc.subject.meshHost-Pathogen Interactions es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLipid Droplets es_ES
dc.subject.meshLipopolysaccharides es_ES
dc.subject.meshMacrophages es_ES
dc.subject.meshMale es_ES
dc.subject.meshMice es_ES
dc.subject.meshMice, Inbred C57BL es_ES
dc.subject.meshMitochondria es_ES
dc.titleMammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID33060333es_ES
dc.format.volume370es_ES
dc.format.number6514es_ES
dc.identifier.doi10.1126/science.aay8085es_ES
dc.contributor.funderFundació La Maratóes_ES
dc.contributor.funderAustralian Research Counciles_ES
dc.contributor.funderSwiss National Science Foundationes_ES
dc.contributor.funderNational Health and Medical Research Council (Australia)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderMinisterio de Ciencia e Innovación (España)es_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderConselho Nacional de Desenvolvimento Científico e Tecnológico (Brazil)es_ES
dc.contributor.funderWorldwide Cancer Researches_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1126/science.aay8085es_ES
dc.identifier.journalScience (New York, N.Y.)es_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización por Integrinases_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Proteómica / Metabolómicaes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Proteómica cardiovasculares_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI19/01410es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-098593-B-I00es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-51876-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-83130-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/ MINSEV1512-07-2016es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BIO2015-67580-Pes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional