Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/10879
Serum Phospholipid Fatty Acids Levels, Anthropometric Variables and Adiposity in Spanish Premenopausal Women
del Pozo, María del Pilar | Criado-Navarro, Inmaculada | Romieu, Isabelle | Chajès, Véronique | Priego-Capote, Feliciano | Pollan-Santamaria, Marina ISCIII | Perez-Gomez, Beatriz ISCIII | Sierra, María Ángeles ISCIII | de Lucas, Maria Pilar ISCIII | Castello, Adela ISCIII | Ruiz, Emma ISCIII | Fernandez de Larrea, Nerea ISCIII | Pastor-Barriuso, Roberto ISCIII | Lope, Virginia ISCIII
Nutrients . 2020 Jun 25;12(6):1895.
This study investigates the still uncertain association between serum phospholipid fatty acids (PL-FA), and anthropometric and adiposity variables. A cross-sectional study was conducted with 1443 Spanish premenopausal women. Participants answered an epidemiological and a food frequency questionnaire. Anthropometric variables were measured using a bioimpedance scale. Serum PL-FAs levels were determined by gas chromatography-mass spectrometry. The association between body mass index (BMI), weight gain, body fat percentage, visceral fat index, and waist circumference with serum PL-FAs and desaturation indices was evaluated using multivariable linear regression models. BMI was positively associated with the relative concentration of saturated fatty acids (SFAs) (β = 0.94, q-val = 0.001), and with palmitoleic, dihomo-γ-linolenic (DGLA), arachidonic (AA) and α-linolenic acids, and was inversely associated with oleic, gondoic, trans-vaccenic, linoleic and γ-linolenic acids. Total fat percentage was positively associated with DGLA and AA, and inversely with linoleic and γ-linolenic acids. Low relative concentrations of some SFAs and high levels of n-6 PUFAs were associated with greater waist circumference. While the oleic/stearic and AA/DGLA acid ratios were inversely associated with BMI, DGLA/linoleic acid ratio was positively related to almost all variables. In addition to BMI, total fat percentage and waist circumference were also associated with certain individual fatty acids.
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