Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/10702
Título
Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression.
Autor(es)
Lolo, Fidel Nicolas CNIC | Jimenez-Jimenez, Victor CNIC | Sanchez-Alvarez, Miguel CNIC | del Pozo, Miguel Angel CNIC
Fecha de publicación
2020-06
Cita
Cancer Metastasis Rev. 2020; 39:485–503
Idioma
Inglés
Tipo de documento
journal article
Resumen
Tumor stiffening is a hallmark of malignancy that actively drives tumor progression and aggressiveness. Recent research has shed light onto several molecular underpinnings of this biomechanical process, which has a reciprocal crosstalk between tumor cells, stromal fibroblasts, and extracellular matrix remodeling at its core. This dynamic communication shapes the tumor microenvironment; significantly determines disease features including therapeutic resistance, relapse, or metastasis; and potentially holds the key for novel antitumor strategies. Caveolae and their components emerge as integrators of different aspects of cell function, mechanotransduction, and ECM-cell interaction. Here, we review our current knowledge on the several pivotal roles of the essential caveolar component caveolin-1 in this multidirectional biomechanical crosstalk and highlight standing questions in the field.
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DOI
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