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dc.contributor.authorLolo, Fidel Nicolas 
dc.contributor.authorJimenez-Jimenez, Victor 
dc.contributor.authorSanchez-Alvarez, Miguel 
dc.contributor.authordel Pozo, Miguel Angel 
dc.date.accessioned2020-07-08T08:23:27Z
dc.date.available2020-07-08T08:23:27Z
dc.date.issued2020-06
dc.identifier.citationCancer Metastasis Rev. 2020; 39:485–503es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10702
dc.description.abstractTumor stiffening is a hallmark of malignancy that actively drives tumor progression and aggressiveness. Recent research has shed light onto several molecular underpinnings of this biomechanical process, which has a reciprocal crosstalk between tumor cells, stromal fibroblasts, and extracellular matrix remodeling at its core. This dynamic communication shapes the tumor microenvironment; significantly determines disease features including therapeutic resistance, relapse, or metastasis; and potentially holds the key for novel antitumor strategies. Caveolae and their components emerge as integrators of different aspects of cell function, mechanotransduction, and ECM-cell interaction. Here, we review our current knowledge on the several pivotal roles of the essential caveolar component caveolin-1 in this multidirectional biomechanical crosstalk and highlight standing questions in the field.es_ES
dc.description.sponsorshipResearch in our laboratory has been supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO; SAF2011-25047, SAF2014-51876-R, SAF2017-83130-R, IGP-SO grant MINSEV1512-07-2016, CSD2009-0016 and BFU2016-81912-REDC), and the Worldwide Cancer Research Foundation (no. 15-0404) to M.A.d.P. M.A.d.P is also a member of the Tec4Bio consortium (ref. P2018/NMT4443; “Actividades de I+D entre Grupos de Investigación en Tecnologías,” Comunidad Autónoma de Madrid/FEDER, Spain) and is co-recipient of grants from Fundació LaMarató de TV3 (674/C/2013 and 201936).M.A.d.P’s group received funding from the European Union Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement no. 641639 (BIOPOL ETN), of which V.J-J. was ESR trainee. M.S-A. was recipient of a CNIC IPP fellowship (COFUND programme 2014). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MCNU), and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleTumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID32514892es_ES
dc.format.volume39es_ES
dc.format.number2es_ES
dc.format.page485-503es_ES
dc.identifier.doi10.1007/s10555-020-09900-yes_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)es_ES
dc.contributor.funderWorldwide Cancer Researches_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderFundació La Maratóes_ES
dc.contributor.funderEuropean Uniones_ES
dc.contributor.funderCentro Nacional de Investigaciones Cardiovasculares (CNIC)es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1573-7233es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s10555-020-09900-yes_ES
dc.identifier.journalCancer metastasis reviewses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización por Integrinases_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2011-25047es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-51876-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-83130-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MINSEV1512-07-2016es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2016-81912-REDCes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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