Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/10654
Título
Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes.
Autor(es)
Angel Rico, Miguel | Trento, Alfonsina ISCIII | Melero, Jose Antonio ISCIII | Ramos, Manuel ISCIII | Johnstone, Carolina ISCIII | Val, Margarita del ISCIII | Lopez, Daniel ISCIII
Fecha de publicación
2009
Cita
Immunol Cell Biol . May-Jun 2009;87(4):344-50.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. Although human airway epithelial cells are the main target of HRSV, it has been reported that this virus can also infect professional antigen-presenting cells such as macrophages and dendritic cells, promoting upregulation of maturation markers. Here, we report that mouse spleen B220(+) B lymphocytes were susceptible to HRSV infection in vitro, probably involving a glycosaminoglycan-dependent mechanism. In contrast, neither CD4(+) nor CD8(+) T lymphocytes were infected. In B lymphocytes, HRSV infection upregulated major histocompatibility complex (MHC) class II but not MHC class I molecules and induced the expression of the activation marker CD86.
MESH
Animals | B-Lymphocytes | Biomarkers | CD4-Positive T-Lymphocytes | CD8-Positive T-Lymphocytes | Glycosaminoglycans | Histocompatibility Antigens Class I | Histocompatibility Antigens Class II | Lymphocyte Activation | Mice | Mice, Inbred C57BL | Respiratory Syncytial Virus Infections | Respiratory Syncytial Virus, Human
Versión en línea
DOI
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