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dc.contributor.author | Angel Rico, Miguel | |
dc.contributor.author | Trento, Alfonsina | |
dc.contributor.author | Melero, Jose Antonio | |
dc.contributor.author | Ramos, Manuel | |
dc.contributor.author | Johnstone, Carolina | |
dc.contributor.author | Val, Margarita del | |
dc.contributor.author | Lopez, Daniel | |
dc.date.accessioned | 2020-07-06T05:53:33Z | |
dc.date.available | 2020-07-06T05:53:33Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Immunol Cell Biol . May-Jun 2009;87(4):344-50. | es_ES |
dc.identifier.issn | 0818-9641 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/10654 | |
dc.description.abstract | Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. Although human airway epithelial cells are the main target of HRSV, it has been reported that this virus can also infect professional antigen-presenting cells such as macrophages and dendritic cells, promoting upregulation of maturation markers. Here, we report that mouse spleen B220(+) B lymphocytes were susceptible to HRSV infection in vitro, probably involving a glycosaminoglycan-dependent mechanism. In contrast, neither CD4(+) nor CD8(+) T lymphocytes were infected. In B lymphocytes, HRSV infection upregulated major histocompatibility complex (MHC) class II but not MHC class I molecules and induced the expression of the activation marker CD86. | es_ES |
dc.description.sponsorship | Dr Mark E Peeples (Department of Immunology/Microbiology, Rush‐Presbyterian‐St Luke's Medical Center, Chicago, IL, USA) kindly provided the rgHRSV. Technical assistance of Carmen Mir is gratefully acknowledged. This study was supported by grants from Programa Ramón y Cajal and Fondo de Investigaciones Sanitarias de la Seguridad Social to DL; by grant SAF2006‐07805 from Ministerio de Educación y Ciencia to JAM; by grants from Comunidad de Madrid and SAF‐2004‐00534 from Ministerio de Educación y Ciencia to MDV; and by a joint grant from Instituto de Salud Carlos III to DL, JAM and MDV. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.type.hasVersion | AM | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | B-Lymphocytes | es_ES |
dc.subject.mesh | Biomarkers | es_ES |
dc.subject.mesh | CD4-Positive T-Lymphocytes | es_ES |
dc.subject.mesh | CD8-Positive T-Lymphocytes | es_ES |
dc.subject.mesh | Glycosaminoglycans | es_ES |
dc.subject.mesh | Histocompatibility Antigens Class I | es_ES |
dc.subject.mesh | Histocompatibility Antigens Class II | es_ES |
dc.subject.mesh | Lymphocyte Activation | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Mice, Inbred C57BL | es_ES |
dc.subject.mesh | Respiratory Syncytial Virus Infections | es_ES |
dc.subject.mesh | Respiratory Syncytial Virus, Human | es_ES |
dc.title | Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 19153593 | es_ES |
dc.format.volume | 87 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | 344-50 | es_ES |
dc.identifier.doi | 10.1038/icb.2008.109 | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/icb.2008.109 | es_ES |
dc.identifier.journal | Immunology and cell biology | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/SAF2006‐07805 | es_ES |
dc.relation.projectID | info:eu_repo/grantAgreement/ES/SAF‐2004‐00534 | es_ES |
dc.rights.accessRights | open access | es_ES |