Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/10448
Viral infections of the central nervous system in Spain: a prospective study.
Fedele, Giovanni ISCIII | Vicente, D | Pena, M J | Moreno, A | Niubo, J | Rabella, N | Rubio, G | Pérez-Ruiz, M | Rodríguez-Iglesias, M | Gimeno, C | Eiros, José María | Melón, S | Blasco, MA CNIO | López-Miragaya, I | Varela, E | Martinez-Sapiña, A | Rodríguez, G | Marcos, M Á | Gegúndez, M I | Cilla, G | Gabilondo, I | Navarro, J M | Torres, J | De Ory, Fernando ISCIII | Avellon, Ana ISCIII | Echevarria, Juan Emilio ISCIII | Sanchez, Marina P CNIC | Trallero, Gloria ISCIII | Cabrerizo, Maria ISCIII | Casas, Inmaculada ISCIII | Pozo Sánchez, Francisco ISCIII | Aznar-Lopez, Carolina ISCIII | Castellanos-Nadal, Ana Maria ISCIII | Guisasola, Maria Eulalia ISCIII | Negredo, Anabel ISCIII | Tenorio, Antonio ISCIII | Vazquez-Moron, Sonia ISCIII
J Med Virol . 2013 Mar;85(3):554-62.
The aim of the study was to determine the incidence of viruses causing aseptic meningitis, meningoencephalitis, and encephalitis in Spain. This was a prospective study, in collaboration with 17 Spanish hospitals, including 581 cases (CSF from all and sera from 280): meningitis (340), meningoencephalitis (91), encephalitis (76), febrile syndrome (7), other neurological disorders (32), and 35 cases without clinical information. CSF were assayed by PCR for enterovirus (EV), herpesvirus (herpes simplex [HSV], varicella-zoster [VZV], cytomegalovirus [CMV], Epstein-Barr [EBV], and human herpes virus-6 [HHV-6]), mumps (MV), Toscana virus (TOSV), adenovirus (HAdV), lymphocytic choriomeningitis virus (LCMV), West Nile virus (WNV), and rabies. Serology was undertaken when methodology was available. Amongst meningitis cases, 57.1% were characterized; EV was the most frequent (76.8%), followed by VZV (10.3%) and HSV (3.1%; HSV-1: 1.6%; HSV-2: 1.0%, HSV non-typed: 0.5%). Cases due to CMV, EBV, HHV-6, MV, TOSV, HAdV, and LCMV were also detected. For meningoencephalitis, 40.7% of cases were diagnosed, HSV-1 (43.2%) and VZV (27.0%) being the most frequent agents, while cases associated with HSV-2, EV, CMV, MV, and LCMV were also detected. For encephalitis, 27.6% of cases were caused by HSV-1 (71.4%), VZV (19.1%), or EV (9.5%). Other positive neurological syndromes included cerebellitis (EV and HAdV), seizures (HSV), demyelinating disease (HSV-1 and HHV-6), myelopathy (VZV), and polyradiculoneuritis (HSV). No rabies or WNV cases were identified. EVs are the most frequent cause of meningitis, as is HSV for meningoencephalitis and encephalitis. A significant number of cases (42.9% meningitis, 59.3% meningoencephalitis, 72.4% encephalitis) still have no etiological diagnosis.
Adolescent | Adult | Aged | Central Nervous System Infections | Child | Child, Preschool | Female | Humans | Incidence | Infant | Infant, Newborn | Male | Middle Aged | Prospective Studies | Spain | Virus Diseases | Viruses | Young Adult
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