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dc.contributor.authorFedele, Giovanni 
dc.contributor.authorVicente, D
dc.contributor.authorPena, M J
dc.contributor.authorMoreno, A
dc.contributor.authorNiubo, J
dc.contributor.authorRabella, N
dc.contributor.authorRubio, G
dc.contributor.authorPérez-Ruiz, M
dc.contributor.authorRodríguez-Iglesias, M
dc.contributor.authorGimeno, C
dc.contributor.authorEiros, José María
dc.contributor.authorMelón, S
dc.contributor.authorBlasco, MA 
dc.contributor.authorLópez-Miragaya, I
dc.contributor.authorVarela, E
dc.contributor.authorMartinez-Sapiña, A
dc.contributor.authorRodríguez, G
dc.contributor.authorMarcos, M Á
dc.contributor.authorGegúndez, M I
dc.contributor.authorCilla, G
dc.contributor.authorGabilondo, I
dc.contributor.authorNavarro, J M
dc.contributor.authorTorres, J
dc.contributor.authorDe Ory, Fernando 
dc.contributor.authorAvellon, Ana 
dc.contributor.authorEchevarria, Juan Emilio 
dc.contributor.authorSanchez, Marina P 
dc.contributor.authorTrallero, Gloria 
dc.contributor.authorCabrerizo, Maria 
dc.contributor.authorCasas, Inmaculada 
dc.contributor.authorPozo Sánchez, Francisco 
dc.contributor.authorAznar-Lopez, Carolina 
dc.contributor.authorCastellanos-Nadal, Ana Maria 
dc.contributor.authorGuisasola, Maria Eulalia 
dc.contributor.authorNegredo, Anabel 
dc.contributor.authorTenorio, Antonio 
dc.contributor.authorVazquez-Moron, Sonia
dc.identifier.citationJ Med Virol . 2013 Mar;85(3):554-62.es_ES
dc.description.abstractThe aim of the study was to determine the incidence of viruses causing aseptic meningitis, meningoencephalitis, and encephalitis in Spain. This was a prospective study, in collaboration with 17 Spanish hospitals, including 581 cases (CSF from all and sera from 280): meningitis (340), meningoencephalitis (91), encephalitis (76), febrile syndrome (7), other neurological disorders (32), and 35 cases without clinical information. CSF were assayed by PCR for enterovirus (EV), herpesvirus (herpes simplex [HSV], varicella-zoster [VZV], cytomegalovirus [CMV], Epstein-Barr [EBV], and human herpes virus-6 [HHV-6]), mumps (MV), Toscana virus (TOSV), adenovirus (HAdV), lymphocytic choriomeningitis virus (LCMV), West Nile virus (WNV), and rabies. Serology was undertaken when methodology was available. Amongst meningitis cases, 57.1% were characterized; EV was the most frequent (76.8%), followed by VZV (10.3%) and HSV (3.1%; HSV-1: 1.6%; HSV-2: 1.0%, HSV non-typed: 0.5%). Cases due to CMV, EBV, HHV-6, MV, TOSV, HAdV, and LCMV were also detected. For meningoencephalitis, 40.7% of cases were diagnosed, HSV-1 (43.2%) and VZV (27.0%) being the most frequent agents, while cases associated with HSV-2, EV, CMV, MV, and LCMV were also detected. For encephalitis, 27.6% of cases were caused by HSV-1 (71.4%), VZV (19.1%), or EV (9.5%). Other positive neurological syndromes included cerebellitis (EV and HAdV), seizures (HSV), demyelinating disease (HSV-1 and HHV-6), myelopathy (VZV), and polyradiculoneuritis (HSV). No rabies or WNV cases were identified. EVs are the most frequent cause of meningitis, as is HSV for meningoencephalitis and encephalitis. A significant number of cases (42.9% meningitis, 59.3% meningoencephalitis, 72.4% encephalitis) still have no etiological diagnosis.es_ES
dc.description.sponsorshipGrant sponsor: Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness; Grant number: PI07/90154es_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAged es_ES
dc.subject.meshCentral Nervous System Infections es_ES
dc.subject.meshChild es_ES
dc.subject.meshChild, Preschool es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshIncidence es_ES
dc.subject.meshInfant es_ES
dc.subject.meshInfant, Newborn es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshProspective Studies es_ES
dc.subject.meshSpain es_ES
dc.subject.meshVirus Diseases es_ES
dc.subject.meshViruses es_ES
dc.subject.meshYoung Adult es_ES
dc.titleViral infections of the central nervous system in Spain: a prospective study.es_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderFondo de Investigaciones Sanitarias
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.identifier.journalJournal of medical virologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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