Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/10395
Título
Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance.
Autor(es)
Braza, Mounia S | Garcia, Mercedes | Brahmachary, Manisha | Pothula, Venu | Fay, Francois | Boros, Peter | Werner, Sherry A | Ginhoux, Florent | Mulder, Willem J M | Ochando, Jordi ISCIII | Conde-San Román, Patricia ISCIII | Cortegano, Isabel ISCIII
Fecha de publicación
2018
Cita
Am J Transplant . 2018 May;18(5):1247-1255.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The colony-stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1-mediated macrophage development remain to be elucidated. Here we demonstrate that neutrophil-derived CSF1 controls macrophage polarization and proliferation, which is necessary for the induction of tolerance. Inhibiting neutrophil production of CSF1 or preventing macrophage proliferation, using targeted nanoparticles loaded with the cell cycle inhibitor simvastatin, abrogates the induction of tolerance. These results provide new mechanistic insights into the developmental requirements of tolerogenic macrophages and identify CSF1 producing neutrophils as critical regulators of the immunological response.
MESH
Heart Transplantation | Animals | Cell Differentiation | Cell Proliferation | Female | Humans | Immune Tolerance | Macrophage Colony-Stimulating Factor | Macrophages | Male | Mice | Mice, Inbred BALB C | Mice, Inbred C57BL | Neutrophils | Signal Transduction | Transplantation Tolerance
Versión en línea
DOI
Aparece en las colecciones