2024-03-28T21:57:59Zhttp://repisalud.isciii.es/oai/requestoai:repisalud.isciii.es:20.500.12105/103952023-12-21T10:22:35Zcom_20.500.12105_2060com_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_2061
00925njm 22002777a 4500
dc
Braza, Mounia S
author
Garcia, Mercedes
author
Brahmachary, Manisha
author
Pothula, Venu
author
Fay, Francois
author
Boros, Peter
author
Werner, Sherry A
author
Ginhoux, Florent
author
Mulder, Willem J M
author
Ochando, Jordi
author
Conde-San Román, Patricia
author
Cortegano, Isabel
author
2018
The colony-stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1-mediated macrophage development remain to be elucidated. Here we demonstrate that neutrophil-derived CSF1 controls macrophage polarization and proliferation, which is necessary for the induction of tolerance. Inhibiting neutrophil production of CSF1 or preventing macrophage proliferation, using targeted nanoparticles loaded with the cell cycle inhibitor simvastatin, abrogates the induction of tolerance. These results provide new mechanistic insights into the developmental requirements of tolerogenic macrophages and identify CSF1 producing neutrophils as critical regulators of the immunological response.
Am J Transplant . 2018 May;18(5):1247-1255.
http://hdl.handle.net/20.500.12105/10395
29314558
10.1111/ajt.14645
1600-6143
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance.