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dc.contributor.authorTa Tang, Thuy-Huong 
dc.contributor.authorCrainey, James L
dc.contributor.authorPost, Rory J
dc.contributor.authorLuz, Sergio Lb
dc.contributor.authorRubio Muñoz, Jose Miguel 
dc.date.accessioned2020-04-30T07:01:54Z
dc.date.available2020-04-30T07:01:54Z
dc.date.issued2018
dc.identifier.citationRes Rep Trop Med. 2018 Jan 18;9:9-24.es_ES
dc.identifier.issn1179-7282es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/9815
dc.description.abstractMansonellosis is a filarial disease caused by three species of filarial (nematode) parasites (Mansonella perstans, Mansonella streptocerca, and Mansonella ozzardi) that use humans as their main definitive hosts. These parasites are transmitted from person to person by bloodsucking females from two families of flies (Diptera). Biting midges (Ceratopogonidae) transmit all three species of Mansonella, but blackflies (Simuliidae) are also known to play a role in the transmission of M. ozzardi in parts of Latin America. M. perstans and M. streptocerca are endemic in western, eastern, and central Africa, and M. perstans is also present in the neotropical region from equatorial Brazil to the Caribbean coast. M. ozzardi has a patchy distribution in Latin America and the Caribbean. Mansonellosis infections are thought to have little pathogenicity and to be almost always asymptomatic, but occasionally causing itching, joint pains, enlarged lymph glands, and vague abdominal symptoms. In Brazil, M. ozzardi infections are also associated with corneal lesions. Diagnosis is usually performed by detecting microfilariae in peripheral blood or skin without any periodicity. There is no standard treatment at present for mansonellosis. The combination therapy of diethylcarbamazine plus mebendazole for M. perstans microfilaremia is presently one of the most widely used, but the use of ivermectin has also been proven to be very effective against microfilariae. Recently, doxycycline has shown excellent efficacy and safety when used as an antimicrobial against endosymbiotic Wolbachia bacteria harbored by some strains of M. perstans and M. ozzardi. Diethylcarbamazine and ivermectin have been used effectively to treat M. streptocerca infection. There are at present no estimates of the disease burden caused by mansonellosis, and thus its importance to many global health professionals and policy makers is presently limited to how it can interfere with diagnostic tools used in modern filarial disease control and elimination programs aimed at other species of filariae.es_ES
dc.language.isoenges_ES
dc.publisherDove Medical Press es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectM. ozzardies_ES
dc.subjectM. perstanses_ES
dc.subjectM. streptocercaes_ES
dc.subjectFilariasises_ES
dc.subjectMansonellosises_ES
dc.subjectNeglected diseasees_ES
dc.titleMansonellosis: current perspectiveses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID30050351es_ES
dc.format.volume9es_ES
dc.format.page9-24es_ES
dc.identifier.doi10.2147/RRTM.S125750es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1179-7282es_ES
dc.relation.publisherversionhttps://doi.org/10.2147/RRTM.S125750es_ES
dc.identifier.journalResearch and reports in tropical medicinees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-NoComercial-CompartirIgual 4.0 Internacional